Serum biomarkers, lifetime substance use and conversion to bipolar disorder.

Autor:	Wirowski N; Program in Health and Behavior, Universidade Católica de Pelotas (UCPEL), Pelotas, RS, Brazil., Lobato AS; Program in Health and Behavior, Universidade Católica de Pelotas (UCPEL), Pelotas, RS, Brazil., Bender LV; Program in Health and Behavior, Universidade Católica de Pelotas (UCPEL), Pelotas, RS, Brazil., Cardoso TA; Deakin University, IMPACT-the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Geelong, Australia., Mondin TC; Pro-rectory of Student Affairs, Universidade Federal de Pelotas (UFPEL), Pelotas, RS, Brazil., Souza LDM; Program in Health and Behavior, Universidade Católica de Pelotas (UCPEL), Pelotas, RS, Brazil., Silva RAD; Program in Health and Behavior, Universidade Católica de Pelotas (UCPEL), Pelotas, RS, Brazil., Oses JP; Graduate Program in Biochemistry and Bioprospecting, Universidade Federal de Pelotas (UFPEL), Pelotas, RS, Brazil., Wiener CD; Program in Health and Behavior, Universidade Católica de Pelotas (UCPEL), Pelotas, RS, Brazil., Jansen K; Program in Health and Behavior, Universidade Católica de Pelotas (UCPEL), Pelotas, RS, Brazil., Pedrotti Moreira F; Program in Health and Behavior, Universidade Católica de Pelotas (UCPEL), Pelotas, RS, Brazil. Electronic address: fepedrotti@gmail.com.
Jazyk:	angličtina
Zdroj:	L'Encephale [Encephale] 2024 Nov 06. Date of Electronic Publication: 2024 Nov 06.
DOI:	10.1016/j.encep.2024.06.008
Abstrakt:	Introduction: The diagnostic conversion of major depressive disorder (MDD) to bipolar disorder (BD) is a topic that is currently the subject of several studies. However, there are few studies that clarify the interaction between conversion, substance use and biomarkers. Objectives: The aim of this study was to investigate serum biomarker levels and lifetime substance use as predictors for diagnostic conversion from major depressive disorder to bipolar disorder in an outpatient sample of adults. Methods: This was a prospective longitudinal study nested within a larger two-phase study. Male and female individuals, between the ages of 18 and 60, diagnosed with MDD by the Mini International Neuropsychiatric Interview Plus who participated in the two stages of the study were included. The instrument alcohol smoking and substance involvement screening test (ASSIST) was used to evaluate substance use. The enzyme linked immuno sorbent assay (ELISA) technique was used to measure the levels of the following biomarkers: brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α). Results: The conversion rate from MDD to BD was 12.4%. The prevalence of female individuals, subjects with up to eight years of schooling, who had lifetime psychotic symptoms and reported lifetime use of cocaine was higher among individuals who converted their diagnosis to BD than among individuals who did not (P<0.05). In the crude analysis, there was no interaction between biomarkers and substance use except for NGF with cocaine. Based on the adjusted analysis model, it was observed that the interaction remains (OR: 1.476; 95% CI: 1.019-2.137). Conclusions: Individuals with late diagnosis and treatment of bipolar disorder may have a worse prognosis. Therefore, results suggesting that NGF and cocaine use are potential predictors of conversion to bipolar disorder can help in clinical practice, contributing to the identification of conversion and to more specific therapeutic interventions. (Copyright © 2024 L'Encéphale, Paris. Published by Elsevier Masson SAS. All rights reserved.)
Databáze:	MEDLINE
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