Associations of haematological and inflammatory biomarkers with brain volume in patients with sickle cell anaemia: A cross-sectional retrospective study.

Autor: Majrashi NA; Diagnostic Radiography Technology (DRT) Department, Faculty of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia., Hendi AM; Diagnostic Radiography Technology (DRT) Department, Faculty of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.; Department of Radiology, Faculty of Medicine, Jazan university, Jazan, Saudi Arabia., Dhayihi TM; Diagnostic Radiography Technology (DRT) Department, Faculty of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.; Department of Radiology, Faculty of Medicine, Jazan university, Jazan, Saudi Arabia., Khamesi AM; Radiology Department, Jazan Specialist Hospital, Jazan Health Cluster, Jazan, Saudi Arabia., Masmali MA; Radiology Department, King Fahad Central Hospital, Ministry of Health, Jazan Health Affairs, Jazan, Saudi Arabia., Hakami KJ; Radiology Department, King Fahad Central Hospital, Ministry of Health, Jazan Health Affairs, Jazan, Saudi Arabia., Alyami AS; Diagnostic Radiography Technology (DRT) Department, Faculty of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia., Alwadani B; Diagnostic Radiography Technology (DRT) Department, Faculty of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia., Ageeli WA; Diagnostic Radiography Technology (DRT) Department, Faculty of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia., Madkhali Y; Diagnostic Radiography Technology (DRT) Department, Faculty of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia., Hakamy A; Respiratory Therapy Department, Faculty of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia., Refaee TA; Diagnostic Radiography Technology (DRT) Department, Faculty of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Jazyk: angličtina
Zdroj: Tropical medicine & international health : TM & IH [Trop Med Int Health] 2024 Nov 07. Date of Electronic Publication: 2024 Nov 07.
DOI: 10.1111/tmi.14056
Abstrakt: Sickle cell disease is a genetic disorder characterised by abnormal haemoglobin production. This study aims to investigate the associations between haematological and inflammatory biomarkers and brain volumes in patients with sickle cell anaemia and compare brain structure between patients with sickle cell anaemia and healthy controls. This retrospective cross-sectional study included 130 participants (70 sickle cell anaemia patients and 60 healthy controls) who underwent brain MRI examinations at King Fahad Central Hospital between January 2010 and October 2022. Demographic data and haematological and inflammatory biomarkers were collected to examine their relationships with brain volumes. Brain volumes were measured using FreeSurfer. Specific haematological and inflammatory biomarkers were correlated with brain volume in patients with sickle cell anaemia, p < 0.05. Sickle cell anaemia patients exhibited smaller volumes in the brainstem, corpus callosum and amygdala compared to healthy controls. Males had significantly higher iron levels (p < 0.001) and larger various brain structure volumes (p < 0.05) than females. This study demonstrates significant associations between specific biomarkers and brain volume in sickle cell anaemia patients, underscoring the importance of monitoring these biomarkers for early detection and management of neurological complications in sickle cell anaemia.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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