Anti-Inflammatory Effects of Calcium Hydroxide Combined with Ellagic Acid as Pulp Capping Material: In Vivo Study.
| Autor: | Sari AF; Dental Health Science Programme, Faculty of Dental Medicine, Universitas Airlangga Surabaya, Surabaya, Indonesia., Nirwana I; Department of Dental Materials, Faculty of Dental Medicine, Universitas Airlangga Surabaya, Surabaya, Indonesia., Yuliati A; Department of Dental Materials, Faculty of Dental Medicine, Universitas Airlangga Surabaya, Surabaya, Indonesia., Meizarini A; Department of Dental Materials, Faculty of Dental Medicine, Universitas Airlangga Surabaya, Surabaya, Indonesia., Rahayu RP; Department of Oral Pathology and Maxillofacial, Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia., Palupi R; Department of Dental Public Health, Faculty of Dental Medicine, Universitas Airlangga Surabaya, Surabaya, Indonesia., Alexandra MF; Dental Science Programme, Faculty of Dental Medicine, Universitas Airlangga Surabaya, Surabaya, Indonesia., Nuraida TB; Dental Science Programme, Faculty of Dental Medicine, Universitas Airlangga Surabaya, Surabaya, Indonesia., Surboyo MDC; Department of Oral Medicine, Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia., Shariff KA; School of Materials and Mineral Resource Engineering, Universiti Sains Malaysia, Penang, Malaysia. |
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| Jazyk: | angličtina |
| Zdroj: | European journal of dentistry [Eur J Dent] 2024 Nov 07. Date of Electronic Publication: 2024 Nov 07. |
| DOI: | 10.1055/s-0044-1791243 |
| Abstrakt: | Objectives: Pulp capping is a pivotal treatment in dentistry aimed at preserving pulp vitality. While calcium hydroxide has long been considered the gold standard in pulp capping materials, its long-term use can induce chronic inflammation, ultimately leading to pulp necrosis and affecting human health. In this context, ellagic acid, a natural compound with potent anti-inflammatory properties, emerged as a promising adjunct to mitigate inflammation associated with calcium hydroxide application, thereby sustaining pulp vitality. This study aimed to investigate the inflammatory response by alterations in neutrophil, macrophage, lymphocyte, and tumor necrosis factor-α (TNF-α) expression following the treatment with a combination of calcium hydroxide and ellagic acid. Materials and Methods: Dental pulp perforation was made on 27 male Wistar rats on the upper first molar and then pulp capped with calcium hydroxide and ellagic acid. The pulp of the control positive group was capped with calcium hydroxide, and the control group was not capped. The teeth were then extracted after 1, 3, and 7 days posttreatment. The differences in the number of neutrophils, macrophages, lymphocytes, and TNF-α expression were analyzed using one-way analysis of variance (ANOVA) and Tukey's honestly significant difference (HSD) test. Results: The treatment combination of calcium hydroxide and ellagic acid showed the lowest neutrophil number and TNF-α expression compared with the other groups ( p < 0.05), while the macrophage and lymphocyte numbers were the highest compared with the other groups ( p < 0.05). Conclusion: The combination of calcium hydroxide and ellagic acid as a pulp capping material exhibited a dual effect on the inflammatory response in dental pulp. These findings suggest that calcium hydroxide and ellagic acid modulate the inflammatory response in a complex manner, promoting a more controlled and potentially beneficial healing process. Competing Interests: None declared. (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).) |
| Databáze: | MEDLINE |
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