Effects of Growth Hormone on Osteoarthritis Development.

Autor:	Sun L; Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China., Gang X; Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China., Li F; Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China., Guo W; Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China., Cui M; Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China., Wang G; Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.
Jazyk:	angličtina
Zdroj:	Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme [Horm Metab Res] 2024 Nov; Vol. 56 (11), pp. 761-769. Date of Electronic Publication: 2024 Nov 07.
DOI:	10.1055/a-2411-9344
Abstrakt:	Osteoarthritis (OA), a chronic joint disease characterized by primary or secondary degeneration of articular cartilage and bone dysplasia, is associated with various risk factors and is the leading cause of musculoskeletal pain and disability, severely impacting the quality of life. Growth hormone (GH), secreted by the anterior pituitary gland, is essential in mediating the growth and development of bone and cartilage. Reportedly, osteoarthritis increases, and the growth hormone decreases with age. A negative correlation between GH and OA suggests that GH may be related to the occurrence and development of OA. Considering that abnormal growth hormone levels can lead to many diseases related to bone growth, we focus on the relationship between GH and OA. In this review, we will explain the effects of GH on the growth and deficiency of bone and cartilage based on the local pathological changes of osteoarthritis. In addition, the potential feasibility of treating OA with GH will be further explored and summarized. Competing Interests: The authors declare that they have no conflict of interest. (Thieme. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu