Maintenance and functional regulation of immune memory to COVID-19 vaccines in tissues.

Autor:	Davis-Porada J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY 10032, USA., George AB; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Lam N; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Caron DP; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Gray JI; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Huang J; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Hwu J; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Wells SB; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Matsumoto R; Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Kubota M; Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Lee Y; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Morrison-Colvin R; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Jensen IJ; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Ural BB; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Shaabani N; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA., Weiskopf D; Center of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Grifoni A; Center of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Sette A; Center of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Szabo PA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Teijaro JR; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: pas2182@cumc.columbia.edu., Farber DL; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: df2396@cumc.columbia.edu.
Jazyk:	angličtina
Zdroj:	Immunity [Immunity] 2024 Oct 29. Date of Electronic Publication: 2024 Oct 29.
DOI:	10.1016/j.immuni.2024.10.003
Abstrakt:	Memory T and B cells in tissues are essential for protective immunity. Here, we performed a comprehensive analysis of the tissue distribution, phenotype, durability, and transcriptional profile of COVID-19 mRNA vaccine-induced immune memory across blood, lymphoid organs, and lungs obtained from 63 vaccinated organ donors aged 23-86, some of whom experienced SARS-CoV-2 infection. Spike (S)-reactive memory T cells were detected in lymphoid organs and lungs and variably expressed tissue-resident markers based on infection history, and S-reactive B cells comprised class-switched memory cells resident in lymphoid organs. Compared with blood, S-reactive tissue memory T cells persisted for longer times post-vaccination and were more prevalent with age. S-reactive T cells displayed site-specific subset compositions and functions: regulatory cell profiles were enriched in tissues, while effector and cytolytic profiles were more abundant in circulation. Our findings reveal functional compartmentalization of vaccine-induced T cell memory where surveilling effectors and in situ regulatory responses confer protection with minimal tissue damage. Competing Interests: Declaration of interests A.S. is a consultant for Gritstone Bio, Flow Pharma, Moderna, AstraZeneca, Qiagen, Fortress, Gilead, Sanofi, Merck, RiverVest, MedaCorp, Turnstone, NA Vaccine Institute, Emervax, Gerson Lehrman Group, and Guggenheim. La Jolla Institute. has filed for patent protection for various aspects of T cell epitope and vaccine design work. Columbia University has filed patent applications related to vaccine tissue assays. (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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