Investigation of brain diffusion changes in children with primary nephrotic syndrome.

Autor: Dogan F; Harran University, Department of Radiology, Sanliurfa, Turkey. Electronic address: feritdogan2001@yahoo.com., Yilmaz K; Specialist Dr. Sanliurfa Training and Research Hospital, Department of Pediatric Nephrology, Sanliurfa, Turkey. Electronic address: kenanylmz68@hotmail.com., Gumus H; Harran University, Faculty of Medicine, Department of Pediatrics, Sanliurfa, Turkey. Electronic address: huseyingumus2163@hotmail.com., Karayol SS; Harran University, Department of Radiology, Sanliurfa, Turkey. Electronic address: ssibelkarayol@gmail.com., Gencler A; Harran University, Faculty of Medicine, Department of Pediatric Nephrology, Sanliurfa, Turkey. Electronic address: aylinsam@gmail.com., Kose D; Harran University, Faculty of Medicine, Department of Pediatric Oncology, Sanliurfa, Turkey. Electronic address: drdogankose@gmail.com.
Jazyk: angličtina
Zdroj: Clinical radiology [Clin Radiol] 2024 Oct 09; Vol. 80, pp. 106720. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1016/j.crad.2024.10.003
Abstrakt: Aim: Primary nephrotic syndrome, which occurs with the deterioration of kidney function, can subsequently affect the brain with systemic immune activation, vasculopathy and ischemia. The main aim of this study was to investigate the effectiveness of apparent diffusion coefficient (ADC) and diffusion weighted imaging (DWI) in identifying and detecting brain changes in pediatric patients with primary nephrotic syndrome (PNS).
Materials and Methods: The study included 24 pediatric patients with PNS and 60 healthy children as a control group. The apparent diffusion coefficient values of caudate nucleus, frontal cortex, thalamus, lentiform nucleus, anterior crus and posterior crus of the internal capsule, frontal and occipital white matter were measured quantitatively.
Results: The ADC values of thalamus, occipital white matter, caudate nucleus and frontal cortex in the PNS group were significantly lower than in the control group (p < 0.05 for all). No statistically significant difference was detected between the groups with respect of other brain locations.
Conclusion: Systemic effects and possible complications of primary nephrotic syndrome may lead to diffusion changes in brain tissue. The decrease in ADC values in patients with PNS may be explained by decreased cerebral perfusion due to cerebral vasoconstriction and vasculopathy.
Competing Interests: Conflict of interest The authors declare no conflict of interest.
(Copyright © 2024 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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