The strength of interspecies interaction in a microbial community determines its susceptibility to invasion.
| Autor: | Muzafar S; Dept. of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden., Nair RR; Dept. of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden., Andersson DI; Dept. of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden., Warsi OM; Dept. of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden. |
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| Jazyk: | angličtina |
| Zdroj: | PLoS biology [PLoS Biol] 2024 Nov 07; Vol. 22 (11), pp. e3002889. Date of Electronic Publication: 2024 Nov 07 (Print Publication: 2024). |
| DOI: | 10.1371/journal.pbio.3002889 |
| Abstrakt: | Previous work shows that a host's resident microbial community can provide resistance against an invading pathogen. However, this community is continuously changing over time due to adaptive mutations, and how these changes affect the invasion resistance of these communities remains poorly understood. To address this knowledge gap, we used an experimental evolution approach in synthetic communities of Escherichia coli and Salmonella Typhimurium to investigate how the invasion resistance of this community against a bacterium expressing a virulent phenotype, i.e., colicin secretion, changes over time. We show that evolved communities accumulate mutations in genes involved in carbon metabolism and motility, while simultaneously becoming less resistant to invasion. By investigating two-species competitions and generating a three-species competition model, we show that this outcome is dependent on the strength of interspecies interactions. Our study demonstrates how adaptive changes in microbial communities can make them more prone to the detrimental effects of an invading species. Competing Interests: The authors have declared that no competing interests exist. (Copyright: © 2024 Muzafar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) |
| Databáze: | MEDLINE |
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