Effect of different running protocols on bone morphology and microarchitecture of the forelimbs in a male Wistar rat model.

Autor: Xavier A; Laboratoire B3OA UMR7052 CNRS U1271 INSERM, Université de Paris, Paris, France.; Laboratoire INEM UMR7355 CNRS, Université d'Orléans, Orléans, France.; Sport, Physical Activity, Rehabilitation and Movement for Performance and Health (SAPRéM), Université d'Orléans, Orléans, France., Bourzac C; Laboratoire B3OA UMR7052 CNRS U1271 INSERM, Université de Paris, Paris, France.; Plateforme de Recherche Biomédicale, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France., Bensidhoum M; Laboratoire B3OA UMR7052 CNRS U1271 INSERM, Université de Paris, Paris, France., Mura C; Laboratoire INEM UMR7355 CNRS, Université d'Orléans, Orléans, France., Portier H; Laboratoire B3OA UMR7052 CNRS U1271 INSERM, Université de Paris, Paris, France., Pallu S; Laboratoire B3OA UMR7052 CNRS U1271 INSERM, Université de Paris, Paris, France.; Sport, Physical Activity, Rehabilitation and Movement for Performance and Health (SAPRéM), Université d'Orléans, Orléans, France.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Nov 07; Vol. 19 (11), pp. e0308974. Date of Electronic Publication: 2024 Nov 07 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0308974
Abstrakt: Background: It is accepted that the metabolic response of bone tissue depends on the intensity of the mechanical loads, but also on the type and frequency of stress applied to it. Physical exercise such as running involves stresses which, under certain conditions, have been shown to have the best osteogenic effects. However, at high intensity, it can be deleterious for bone tissue. Consequently, there is no clear consensus as to which running modality would have the best osteogenic effects.
Aim: Our objective was to compare the effects of three running modalities on morphological and micro-architectural parameters on forelimb bones.
Methods: Forty male Wistar rats were randomly divided into four groups: high intensity interval training (HIIT), continuous running, combined running ((alternating HIIT and continuous modalities) and sedentary (control). The morphometry, trabecular microarchitecture and cortical porosity of the ulna, radius and humerus were analyzed using micro-tomography.
Results: All three running modalities resulted in bone adaptation, with an increase in the diaphyseal diameter of all three bones. The combined running protocol had positive effects on the trabecular thickness in the distal ulna. The HIIT protocol resulted in an increase in both medio-lateral diameter and cortical bone area over total area (Ct.Ar/Tt.Ar) at the ulnar shaft compared with sedentary condition. Moreover, the HIIT protocol decreased the mean surface area of the medulla (Ma.Ar) according to sedentary condition at the ulnar shaft.
Conclusion: This study has shown that HIIT resulted in a decrease in trabecular bone fraction in favor of cortical bone area at the ulna.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Xavier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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