Avidity maturation of anti-spike IgG after vaccination in COVID-19 convalescent vs COVID-19 naïve patients.

Autor: Löfström E; Department of Clinical Sciences, Lund University, Office DCSL, Lund, Sweden.; Department of Clinical Microbiology, Hallands hospital Halmstad, Halmstad, Sweden., Eringfält A; Department of Clinical Microbiology, Hallands hospital Halmstad, Halmstad, Sweden., Kötz A; Department of Clinical Microbiology, Hallands hospital Halmstad, Halmstad, Sweden., Tham J; Department of Translational Medicine, Clinical Infection Medicine, Lund University, Skåne University Hospital, Malmö, Sweden., Undén J; Department of Clinical Sciences, Lund University, Office DCSL, Lund, Sweden.; Department of Operation and Intensive care, Hallands hospital Halmstad, Halmstad, Sweden.
Jazyk: angličtina
Zdroj: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2025 Jan; Vol. 133 (1), pp. e13489. Date of Electronic Publication: 2024 Nov 07.
DOI: 10.1111/apm.13489
Abstrakt: Antibodies and avidity maturation contribute to long-lasting immunity, and previous COVID-19 seems to enhance the immune response after vaccination. The aim of this study was to compare the immune response after vaccination between COVID-19 convalescents and naïve patients. Blood samples from COVID-19 convalescents and naïve patients, taken 1, 3 and 6 months after the second dose of vaccine (mRNA-vaccine BNT162b2), were analysed for anti-spike IgG and avidity. Questionnaires concerning side effects were used. Thirty-one patients in the COVID-19 cohort and 30 patients in the naïve cohort were included. High levels of anti-spike IgG and avidity index were seen. Anti-spike IgG were significantly higher in the COVID-19 cohort and declining (median 1250, 566, 282 RU/ml vs 565, 187, 65 RU/ml). Avidity did not change over time (median at 6 months 78% vs 65%). The most common side effects were pain at the injection site, malaise and headache. In conclusion, high levels of anti-spike IgG after vaccination were seen and most patients developed high-avidity antibodies, although antibody levels and avidity were higher in the COVID-19 cohort. Over time, the levels of anti-spike IgG declined, yet avidity remained high. Side effects did not differ between groups and were of short duration.
(© 2024 The Author(s). APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Pathology, Medical Microbiology and Immunology.)
Databáze: MEDLINE
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