TERT Gene Mutation in Gliomas Cross-Linked With (NTRK, PDL1, ALK, IDH, P53, EGFR, HER2): A Integrative Review TERT Gene Mutation in Gliomas.

Autor: Santos GG; Departamento de Patologia e Medicina Legal, Universidade Federal do Ceará, Fortaleza, Brazil., Nogueira GN; Clinical Medicine Department, Universidade Federal do Ceará, Fortaleza, Brazil., Saldanha IMR; Clinical Medicine Department, Universidade Federal do Ceará, Fortaleza, Brazil., Farias AGP; Clinical Medicine Department, Universidade Federal do Ceará, Fortaleza, Brazil., Mateus CM; Clinical Medicine Department, Universidade Federal do Ceará, Fortaleza, Brazil., Neto OMV; Clinical Medicine Department, Universidade Federal do Ceará, Fortaleza, Brazil., Teixeira MJ; Departamento de Patologia e Medicina Legal, Universidade Federal do Ceará, Fortaleza, Brazil.
Jazyk: angličtina
Zdroj: Journal of surgical oncology [J Surg Oncol] 2024 Nov 07. Date of Electronic Publication: 2024 Nov 07.
DOI: 10.1002/jso.27986
Abstrakt: Introduction: Recent advancements in glioma treatment are largely driven by the identification of genetic alterations, which enhance diagnostic precision and prognostic assessments, and unveil potential therapeutic targets. TERT promoter mutations, in particular, are associated with a poorer prognosis and aggressive clinical behavior.
Methodology: This study explores the genetic interplay between TERT and other genes (ntrk, pdl1, alk, idh, p53, egfr, her2) in brain tumors through an integrative literature review. This method synthesizes evidence from selected articles spanning 2014 to 2023.
Results: The review identified 65 articles based on defined inclusion criteria, out of which 14 were analyzed in depth. Findings reveal that TERT, TP53, and IDH1 are the most frequently mutated genes in gliomas. The prognosis of glioma patients can be refined through the combined analysis of IDH and TERT mutations. Additionally, PD-L1 expression levels are associated with prognosis and may influence treatment responses, particularly, in immunotherapy.
Discussion: The study underscores the importance of molecular diagnostics, such as Next-Generation Sequencing (NGS), in detecting key genetic mutations. These advancements have paved the way for new therapeutic strategies and better patient outcomes. The findings highlight the crucial role of genetic markers in glioma treatment and prognosis, advocating for continued research to enhance clinical applications and patient care.
Conclusion: The use of NGS is indispensable in identifying biomarkers associated with mutations in the TERT gene.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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