Impaired Glucose Homeostasis Accompanies Cellular Changes in Endocrine Pancreas after Atorvastatin Administration.
| Autor: | Abdel-Hamid AAM; Department of Anatomy, Taibah College of Medicine, Taibah University, Almadina Almonawara, Kingdom of Saudi Arabia.; Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt., Firgany AEL; Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt.; Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Kingdom of Saudi Arabia. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of microscopy and ultrastructure [J Microsc Ultrastruct] 2024 Jun 20; Vol. 12 (3), pp. 126-133. Date of Electronic Publication: 2024 Jun 20 (Print Publication: 2024). |
| DOI: | 10.4103/jmau.jmau_41_21 |
| Abstrakt: | Atorvastatin (ATOR) has been reported to increase the risk for diabetes mellitus. Therefore, in the current study, we focused on studying the effect of ATOR on the structure of islets of Langerhans including their various cellular components as well as on glucose homeostasis. We detected a statistically significant increase ( P < 0.05) in β-cell mass and percentage with a significant decrease in α-cell area and percentage in animals that received ATOR compared to control ones. In addition, a statistically significant increase ( P < 0.05) in the β-cell proliferation was observed in the ATOR group with negligible change in expression of inflammatory cytokines of the islets. A significant downregulation in apoptosis alongside a significant upregulation in anti-apoptosis were detected in islets of animals treated with ATOR. Moreover, there was a significant impairment in various parameters of glucose homeostasis in the ATOR-treated group. Therefore, ATOR may induce insulin resistance-like state that was demarcated at cellular as well as at biochemical levels with little or no inflammatory response. Competing Interests: There is no conflict of interest. (Copyright: © 2024 Journal of Microscopy and Ultrastructure.) |
| Databáze: | MEDLINE |
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