Efficient Dehydration of 1-Phenylethanol to Styrene by Copper(II) and Zinc(II) Fused-Bisoxazolidine Catalysts.

Autor: Panda A; Department of Chemistry, University of Rochester, Rochester, New York 14627, United States., Wood CR; Department of Chemistry, University of Rochester, Rochester, New York 14627, United States., Brennessel WW; Department of Chemistry, University of Rochester, Rochester, New York 14627, United States., Jones WD; Department of Chemistry, University of Rochester, Rochester, New York 14627, United States.
Jazyk: angličtina
Zdroj: ACS catalysis [ACS Catal] 2024 Oct 11; Vol. 14 (21), pp. 15927-15934. Date of Electronic Publication: 2024 Oct 11 (Print Publication: 2024).
DOI: 10.1021/acscatal.4c04572
Abstrakt: The air-stable copper(II) catalyst [Cu( meso FOX-L1)(MeCN)][OTf] 2 ( 2a ) is prepared from a fused meso-dipyridylbisoxazolidine ( meso FOX-L1) and CuBr 2 , followed by treatment with AgOTf. The compound is a catalyst for the dehydration of 1-phenylethanol to styrene (+H 2 O) in over 95% yield at 1 mol % catalyst loading. Other alcohols (benzylic, tertiary, or allylic) are also efficiently dehydrated by this catalyst. Water separation in toluene solvent is found to play an important role in the reaction. Related compounds with Zn(II) have been prepared and display reduced dehydration activity.
Competing Interests: The authors declare no competing financial interest.
(© 2024 The Authors. Published by American Chemical Society.)
Databáze: MEDLINE
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