Abscopal effect induced by cryoablation in a 55-year-old patient with metastatic dedifferentiated liposarcoma: a case report.

Autor:	Wetterwald L; Department of Oncology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Papadopoulos S; Department of Oncology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Tsoumakidou G; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Boughdad S; Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Ferraro D; Department of Oncology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Koulouris P; Department of Oncology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Cherix S; Department of Orthopaedics and Traumatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Duran R; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Digklia A; Department of Oncology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Jazyk:	angličtina
Zdroj:	Annals of translational medicine [Ann Transl Med] 2024 Oct 20; Vol. 12 (5), pp. 94. Date of Electronic Publication: 2024 Oct 15.
DOI:	10.21037/atm-23-1868
Abstrakt:	Background: Metastatic dedifferentiated liposarcoma (DDLPS) is primarily managed with chemotherapy, yet with poor response rate. Locoregional therapies, such as radiotherapy and percutaneous cryoablation, can provide palliation for inoperable metastatic sarcomas. In rare instances, those ablative therapies can elicit an immune-mediated regression of untreated metastases in a process named the abscopal effect. With the growing use of immunotherapy, reports on the abscopal effect have become more frequent during the last decade. Case Description: A 55-year-old patient with no prior medical history was diagnosed with a stage IV DDLPS. The patient was first treated with induction chemotherapy followed by en bloc resection and adjuvant radiotherapy. After two local relapses treated with chemotherapy, the patient developed a systemic disease progression. While progressing on immunochemotherapy, the patient underwent palliative percutaneous cryoablation. Three months after the procedure, the 18 fluorodeoxyglucose positron emission tomography/computed tomography ( 18 FDG PET/CT) showed regression of the distant metastasis alongside the regression of the cryoablated tumor, suggesting an abscopal effect. Conclusions: The occurrence of the abscopal effect after progressive disease suggests that cryoablation triggered a systemic immune response, highlighting the potential of this treatment combination. However, it remains a rare phenomenon, and further research and clinical trials are required to determine optimal treatment sequencing. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://atm.amegroups.com/article/view/10.21037/atm-23-1868/coif). R.D. reports payment or honoraria via institution by Society of Interventional Oncology, Boston Scientific, Guerbet and BTG. A.D. reports payment or honoraria via the institution by Genentech/Roche, Pharmamar, Traconpharma, AstraZeneca, Boston Scientific and Bristol-Myers Squibb. The other authors have no conflicts of interest to declare. (2024 AME Publishing Company. All rights reserved.)
Databáze:	MEDLINE
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