Delineating sex-specific circulating host response signatures associated with COVID-19 severity and mortality.

Autor:	Keur N; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud UMC, Nijmegen, the Netherlands., Flikweert AW; Department of Pulmonary Medicine, Amphia Hospital, Breda, the Netherlands.; Department of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Ricaño-Ponce I; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud UMC, Nijmegen, the Netherlands., Muller Kobold AC; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., van der Sar-van der Brugge S; Department of Pulmonary Medicine, Amphia Hospital, Breda, the Netherlands., Rodenhuis-Zybert IA; Department of Medical Microbiology & Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Le KTT; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., van Meurs M; Department of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Grootenboers MJ; Department of Pulmonary Medicine, Amphia Hospital, Breda, the Netherlands., van der Voort PHJ; Department of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Heeringa P; Department of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Kumar V; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud UMC, Nijmegen, the Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Moser J; Department of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 Oct 11; Vol. 27 (11), pp. 111150. Date of Electronic Publication: 2024 Oct 11 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.111150
Abstrakt:	Male SARS-CoV-2-infected patients have higher hospitalization rates, ICU admissions, and mortality compared to females, yet with unclear underlying mechanisms. We investigated the influence of biological sex on COVID-19 severity and patient outcomes. We profiled 41 circulating host response markers and identified differentially regulated proteins based on disease severity using covariates, such as sex, age, BMI, diabetes, and corticosteroid administration. IL-8, D-dimer, S100B, IL-6, Angpt-2, MMP-8, TNF-R1, u-PAR, u-PA, osteopontin, IL-13, TNF-α, pentraxin-3, P-selectin, fractalkine, and SP-D levels were elevated in critically ill COVID-19 males compared to severe cases. In contrast, IL-8, D-dimer, IL-6, Angpt-2, Tie-2, uPAR, and SP-D were higher in females with critical-COVID-19 than in severe cases. Notably, D-dimer, IL-6, pentraxin-3, and S100B were associated with male mortality, yet none of the measured plasma proteins associated with female mortality. Our study delineated distinct sex-specific plasma protein signatures linked to the severity and mortality of COVID-19 patients. Competing Interests: The authors declare no competing interests. (© 2024 The Author(s).)
Databáze:	MEDLINE
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