Unraveling In vivo Potential of Curcumin-loaded Graphene Quantum Dots on Drug Delivery and Release Kinetics Aspects of Cancer Treatment.
Autor: | Fahmi MZ; Department of Chemistry, University Airlangga, Surabaya 60115, Indonesia.; Supra Modification Nano-Micro Engineering Research Group, Universitas Airlangga, Surabaya 60115, Indonesia., Sugito SFA; Department of Chemistry, University Airlangga, Surabaya 60115, Indonesia.; Supra Modification Nano-Micro Engineering Research Group, Universitas Airlangga, Surabaya 60115, Indonesia., Wibrianto A; Department of Chemistry, University Airlangga, Surabaya 60115, Indonesia.; Supra Modification Nano-Micro Engineering Research Group, Universitas Airlangga, Surabaya 60115, Indonesia., Novania S; Department of Chemistry, University Airlangga, Surabaya 60115, Indonesia., Widyastuti S; Department of Chemistry, University Airlangga, Surabaya 60115, Indonesia., Ahmad MA; Department of Chemistry, University Airlangga, Surabaya 60115, Indonesia., Sakti SCW; Department of Chemistry, University Airlangga, Surabaya 60115, Indonesia.; Supra Modification Nano-Micro Engineering Research Group, Universitas Airlangga, Surabaya 60115, Indonesia., Voon LH; Nanotechnology and Catalysis Research Centre (NANOCAT), Universiti Malaya, 50603, Kuala Lumpur, Malaysia. |
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Jazyk: | angličtina |
Zdroj: | Nanotheranostics [Nanotheranostics] 2024 Aug 13; Vol. 8 (4), pp. 521-534. Date of Electronic Publication: 2024 Aug 13 (Print Publication: 2024). |
DOI: | 10.7150/ntno.96559 |
Abstrakt: | This study introduces an innovative magnetic-based multifunctional anti-cancer drug carrier aiming to enhance the efficacy of curcumin in cancer therapy. The research investigates the potential of Graphene Quantum Dots (GQDs) as a curcumin drug delivery system for inhibiting in vivo cancer growth. GQDs with a particle diameter below 10 nm were synthesized via hydrothermal and Hummers methods, exhibiting homogeneity and crystalline structure according to AFM and XRD analyses. FTIR analysis confirmed functionalization success, revealing the formation of bonds between GQDs and curcumin. The optical properties of GQDs were assessed using a UV-Vis spectrophotometer and spectrofluorometer, resulting in vigorous fluorescence with a quantum yield of 1.32%. Subsequently, loading curcumin onto GQDs (CQDs/cur) resulted in an efficient system for delivering the anti-cancer drug, demonstrating significant in vivo efficacy. It was indicated by reduced tumor diameter and increased body weight in mice. Furthermore, the release kinetics of curcumin from GQDs were analyzed using the Peppas-Sahlin equation under varying pH conditions (4, 7, and 9), revealing the highest release rate in acidic conditions. In conclusion, this study highlights the potential of GQDs as highly efficient carriers for targeted curcumin delivery, showcasing promising prospects in cancer treatment. Competing Interests: Competing Interests: The authors have declared that no competing interest exists. (© The author(s).) |
Databáze: | MEDLINE |
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