Magnetic resonance imaging-guided single-fraction preoperative radiotherapy for early-stage breast cancer (the RICE trial): feasibility study.

Autor: Qadir A; Department of Medical Imaging and Radiation Sciences, School of Primary and Allied Health Care, Monash University, Melbourne, Australia., Singh N; Department of Medical Imaging and Radiation Sciences, School of Primary and Allied Health Care, Monash University, Melbourne, Australia., Dean J; Department of Radiation Oncology, Newton-John Cancer Wellness and Research Centre, 145 Studley Road, PO Box 5555, Heidelberg , Austin HealthVictoria, Olivia, 3084, Australia., Brown K; Department of Radiation Oncology, Newton-John Cancer Wellness and Research Centre, 145 Studley Road, PO Box 5555, Heidelberg , Austin HealthVictoria, Olivia, 3084, Australia., Tacey M; Department of Radiation Oncology, Newton-John Cancer Wellness and Research Centre, 145 Studley Road, PO Box 5555, Heidelberg , Austin HealthVictoria, Olivia, 3084, Australia., Mann B; Royal Women's Hospital, Parkville, VIC, Australia.; Melbourne University, Parkville, VIC, Australia., Kron T; Melbourne University, Parkville, VIC, Australia.; Peter MacCallum Cancer Centre, Parkville, VIC, Australia., Cahoon G; Department of Radiation Oncology, Newton-John Cancer Wellness and Research Centre, 145 Studley Road, PO Box 5555, Heidelberg , Austin HealthVictoria, Olivia, 3084, Australia., Lau E; Melbourne University, Parkville, VIC, Australia.; Austin Health, Heidelberg, VIC, Australia.; Department of Molecular Imaging, Austin Health and University of Melbourne, Victoria, Australia., Scott AM; School of Cancer Medicine, Olivia Newton John Cancer Research Instituteand, Latrobe University , Melbourne, VIC, Australia.; Department of Molecular Imaging, Austin Health and University of Melbourne, Victoria, Australia., Yeo B; School of Cancer Medicine, Olivia Newton John Cancer Research Instituteand, Latrobe University , Melbourne, VIC, Australia.; Medical Oncology, Austin Health, Heidelberg, VIC, Australia., Loh SW; Breast Surgery, Austin Health, Heidelberg, VIC, Australia., Uribe S; Department of Medical Imaging and Radiation Sciences, School of Primary and Allied Health Care, Monash University, Melbourne, Australia., Moe AAK; Department of Medical Imaging and Radiation Sciences, School of Primary and Allied Health Care, Monash University, Melbourne, Australia., Ireland-Jenkins K; Melbourne University, Parkville, VIC, Australia.; Anatomical Pathology, Austin Health, Heidelberg, VIC, Australia., McAuley R; Department of Radiation Oncology, Newton-John Cancer Wellness and Research Centre, 145 Studley Road, PO Box 5555, Heidelberg , Austin HealthVictoria, Olivia, 3084, Australia., McDermont L; Department of Radiation Oncology, Newton-John Cancer Wellness and Research Centre, 145 Studley Road, PO Box 5555, Heidelberg , Austin HealthVictoria, Olivia, 3084, Australia., Ooi WM; Breast Surgery, Austin Health, Heidelberg, VIC, Australia., Ng S; Breast Surgery, Austin Health, Heidelberg, VIC, Australia., Chao M; Department of Medical Imaging and Radiation Sciences, School of Primary and Allied Health Care, Monash University, Melbourne, Australia.; Department of Radiation Oncology, Newton-John Cancer Wellness and Research Centre, 145 Studley Road, PO Box 5555, Heidelberg , Austin HealthVictoria, Olivia, 3084, Australia., Foroudi F; Department of Medical Imaging and Radiation Sciences, School of Primary and Allied Health Care, Monash University, Melbourne, Australia. farshad.foroudi@austin.org.au.; Department of Radiation Oncology, Newton-John Cancer Wellness and Research Centre, 145 Studley Road, PO Box 5555, Heidelberg , Austin HealthVictoria, Olivia, 3084, Australia. farshad.foroudi@austin.org.au.; School of Cancer Medicine, Olivia Newton John Cancer Research Instituteand, Latrobe University , Melbourne, VIC, Australia. farshad.foroudi@austin.org.au.
Jazyk: angličtina
Zdroj: Pilot and feasibility studies [Pilot Feasibility Stud] 2024 Nov 07; Vol. 10 (1), pp. 133. Date of Electronic Publication: 2024 Nov 07.
DOI: 10.1186/s40814-024-01557-6
Abstrakt: Background: Over the past decade, the adoption of screening programs, digital mammography, and magnetic resonance imaging (MRI) has increased early-stage breast cancer diagnosis rates. Mortality rates have decreased due to early detection and improved treatments, including personalized therapies. Accelerated partial-breast irradiation (APBI) is emerging as a convenient and effective treatment for some patients, with studies exploring its preoperative use. Preoperative APBI, especially with MRI guidance, offers improved tumor targeting and potentially reduced side effects. Magnetic Resonance Imaging-Guided Single-Fraction Pre-Operative Radiotherapy for Early-Stage Breast Cancer (RICE trial) aims to assess the feasibility and efficacy of MRI-guided single-dose radiotherapy (RT) for early-stage breast cancer.
Methods: The RICE study is a prospective, single-arm study evaluating single-fraction preoperative, APBI treatment for patients with early-stage breast cancer using a magnetic resonance imaging linear accelerator (MRI linac). Eligible patients enrolled in this study will have a core biopsy to confirm estrogen receptor-positive and HER2-negative sub-type. RT planning will use a planning computed tomography (CT) co-registered with a MRI with the patient in either the supine or prone position. For the diagnostic workup, [18F] fluorodeoxyglucose positron emission tomography/CT ([18F] FDG PET/CT) and [18F] fluoroestradiol positron emission tomography/CT ([18F] FES PET/CT) will be performed prior to treatment. Thirty patients will receive a single ablative RT dose of 21 Gray to the tumor. Pre-treatment and post-treatment MRI scans will be acquired at baseline and 5 weeks post-RT respectively. Breast-conserving surgery will be scheduled for 6 weeks after APBI treatment using the MRI linac. The primary study endpoint is the successful administration of a single fraction of preoperative breast RT under the guidance of an MRI linac. Secondary endpoints include evaluating the utility of MRI, [18F] FDG PET/CT, and [18F] FES PET/CT as a non-invasive method for assessing treatment response in patients undergoing single-fraction preoperative APBI.
Conclusion: The RICE trial represents a significant step in breast cancer treatment, offering insights that could lead to treatment protocols with minimized RT appointments and enhanced patient outcomes.
Trial Registration: This trial is registered with the Australian New Zealand Clinical Trials Registry (ANZCTR). Registered 31st of May 2021.
Registration Number: ACTRN12621000659808 .
(© 2024. The Author(s).)
Databáze: MEDLINE
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