The Effect of Rosuvastatin on Facial Nerve Regeneration After Facial Nerve Injury: An Experimental Animal Study.
| Autor: | Dincer U; Department of ENT, Reyhanli State Hospital, Hatay, Turkey., Verim A; Department of ENT, Haydarpaşa Numune Training and Research Hospital, University of Health Science, İstanbul, Turkey., Becerik Ç; Department of ENT, Kemalpaşa State Hospital, İzmir, Turkey., Gürsan N; Department of Pathology,Sancaktepe Sehit Prof Dr Ilhan Varank Training and Research Hospital, University of Health Science, İstanbul, Turkey., Tepe Karaca Ç; Department of ENT, Haydarpaşa Numune Training and Research Hospital, University of Health Science, İstanbul, Turkey., Toros SZ; Department of ENT, Haydarpaşa Numune Training and Research Hospital, University of Health Science, İstanbul, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | The Annals of otology, rhinology, and laryngology [Ann Otol Rhinol Laryngol] 2025 Feb; Vol. 134 (2), pp. 134-141. Date of Electronic Publication: 2024 Nov 06. |
| DOI: | 10.1177/00034894241291814 |
| Abstrakt: | Objectives: Rosuvastatin is an antihyperlipidemic statin group pharmacological agent with antioxidant, neuroprotective, and anti-inflammatory effects. In this study, we aimed to examine the functional, electrophysiological, and histopathological effects of rosuvastatin or in combination with corticosteroids on facial nerve regeneration in rats with traumatic peripheral facial paralysis (PFP). Methods: PFP was induced in 28 female Sprague Dawley rats that we divided into 4 groups: group 1, control group; group 2, methylprednisolone group; group 3, rosuvastatin group; group 4, rosuvastatin and methylprednisolone group. Electrophysiological, functional, and histopathological examinations were performed before and after the medications. Results: Electrophysiological threshold values of group 3 and group 4 were found to be significantly lower than the control group on day 21 after treatment ( P = .002, P = .001; P < .01).In the histopathological evaluation, axonal degeneration, macrovacuolization, and vascular congestion levels were compared between the groups, and a statistically significant difference was observed in group 4 compared to the control group. The recovery time of the eye corneal reflex was found to be significantly higher in the control group than in groups 3 and 4 when comparing postoperative day 1 to day 7 and postoperative day 1 to day 14. Conclusion: Rosuvastatin, especially when combined with methylprednisolone was found to significantly increase the facial nerve electrophysiological, functional, and histopathological recovery in injury-induced traumatic PFP. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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