A multicellular developmental program in a close animal relative.

Autor: Olivetta M; Swiss Institute for Experimental Cancer Research, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.; Department of Biochemistry, University of Geneva, Geneva, Switzerland., Bhickta C; Swiss Institute for Experimental Cancer Research, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland., Chiaruttini N; Bioimaging and Optics Core Facility, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Burns J; Bigelow Laboratory for Ocean Sciences, East Boothbay, ME, USA. jburns@bigelow.org., Dudin O; Swiss Institute for Experimental Cancer Research, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland. omaya.dudin@unige.ch.; Department of Biochemistry, University of Geneva, Geneva, Switzerland. omaya.dudin@unige.ch.
Jazyk: angličtina
Zdroj: Nature [Nature] 2024 Nov; Vol. 635 (8038), pp. 382-389. Date of Electronic Publication: 2024 Nov 06.
DOI: 10.1038/s41586-024-08115-3
Abstrakt: All animals develop from a single-celled zygote into a complex multicellular organism through a series of precisely orchestrated processes 1,2 . Despite the remarkable conservation of early embryogenesis across animals, the evolutionary origins of how and when this process first emerged remain elusive. Here, by combining time-resolved imaging and transcriptomic profiling, we show that single cells of the ichthyosporean Chromosphaera perkinsii-a close relative that diverged from animals about 1 billion years ago 3,4 -undergo symmetry breaking and develop through cleavage divisions to produce a prolonged multicellular colony with distinct co-existing cell types. Our findings about the autonomous and palintomic developmental program of C. perkinsii hint that such multicellular development either is much older than previously thought or evolved convergently in ichthyosporeans.
Competing Interests: Competing interests The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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