Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling.

Autor: Chia ZJ; Institute for Biomedicine and Glycomics, Griffith University, Nathan, QLD, Australia.; School of Pharmacy, The University of Queensland, Woolloongabba, QLD, Australia., Kumarapperuma H; Institute for Biomedicine and Glycomics, Griffith University, Nathan, QLD, Australia.; School of Pharmacy, The University of Queensland, Woolloongabba, QLD, Australia., Zhang R; Institute for Biomedicine and Glycomics, Griffith University, Nathan, QLD, Australia.; School of Environment and Science, Griffith Sciences, Griffith University, Nathan, QLD, Australia., Little PJ; School of Pharmacy, The University of Queensland, Woolloongabba, QLD, Australia.; Department of Pharmacy, Guangzhou Xinhua University, Guangzhou, 510520, China., Kamato D; Institute for Biomedicine and Glycomics, Griffith University, Nathan, QLD, Australia. d.kamato@griffith.edu.au.; School of Pharmacy, The University of Queensland, Woolloongabba, QLD, Australia. d.kamato@griffith.edu.au.; School of Environment and Science, Griffith Sciences, Griffith University, Nathan, QLD, Australia. d.kamato@griffith.edu.au.
Jazyk: angličtina
Zdroj: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2024 Nov 06. Date of Electronic Publication: 2024 Nov 06.
DOI: 10.1038/s41401-024-01413-6
Abstrakt: The Smad transcription factors are well known for their role at the core of transforming growth factor-β (TGF-β) signalling. However, recent evidence shows that the Smad transcription factors play a vital role downstream of other classes of receptors including G protein-coupled receptors (GPCR). The versatility of Smad transcription factors originated from the two regions that can be differently activated by the TGF-β receptor superfamily or through the recruitment of intracellular kinases stimulated by other receptors classes such as GPCRs. The classic GPCR signalling cascade is further expanded to conditional adoption of the Smad transcription factor under the stimulation of Akt, demonstrating the unique involvement of the Smad transcription factor in GPCR signalling pathways in disease environments. In this review, we provide a summary of the signalling pathways of the Smad transcription factors as an important downstream mediator of GPCRs, presenting exciting opportunities for discovering new therapeutic targets for diseases.
(© 2024. The Author(s).)
Databáze: MEDLINE
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