Neutrophil-to-lymphocyte ratio as a prognostic indicator of mortality in Polycythemia Vera: insights from a prospective cohort analysis.
Autor: | Barbui T; FROM, Fondazione per la Ricerca Ospedale di Bergamo ETS, Bergamo, Italy. tbarbui@fondazionefrom.it., Carobbio A; FROM, Fondazione per la Ricerca Ospedale di Bergamo ETS, Bergamo, Italy.; Dipartimento di Scienze Mediche e Chirurgiche, Materno-Infantili e dell'Adulto, Università di Modena-Reggio Emilia, Modena, Italy., Ghirardi A; FROM, Fondazione per la Ricerca Ospedale di Bergamo ETS, Bergamo, Italy., Fenili F; FROM, Fondazione per la Ricerca Ospedale di Bergamo ETS, Bergamo, Italy., Finazzi MC; Divisione di Ematologia, ASST Papa Giovanni XXIII, Bergamo, Italy.; Dipartimento di Oncologia ed Emato-Oncologia, Università degli Studi di Milano, Milan, Italy., Castelli M; Divisione di Ematologia, ASST Papa Giovanni XXIII, Bergamo, Italy., Vannucchi AM; CRIMM, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Florence, Italy., Guglielmelli P; CRIMM, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Florence, Italy., Rambaldi A; Divisione di Ematologia, ASST Papa Giovanni XXIII, Bergamo, Italy.; Dipartimento di Oncologia ed Emato-Oncologia, Università degli Studi di Milano, Milan, Italy., Gangat N; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA., Tefferi A; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA. |
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Jazyk: | angličtina |
Zdroj: | Blood cancer journal [Blood Cancer J] 2024 Nov 06; Vol. 14 (1), pp. 195. Date of Electronic Publication: 2024 Nov 06. |
DOI: | 10.1038/s41408-024-01176-7 |
Abstrakt: | We analyzed the neutrophil-to-lymphocyte ratio (NLR) in 1508 patients with PV and found that those with an NLR ≥ 5 were generally older, had a longer disease history, and had higher cardiovascular risk factors, more arterial thrombosis, and more aggressive blood counts, indicating a more proliferative disease. NLR was an accurate predictor of mortality, with patients with NLR ≥ 5 having significantly worse overall survival and more than twice the mortality rate compared to those with NLR < 5. Multivariable models confirmed that increasing age, previous venous thrombosis and NLR ≥ 5 were strong predictors of death, further influenced by cardiovascular risk factors. We examined the interaction between NLR and the number of cardiovascular risk factors and found a progressive trend of increased mortality risk for NLR values ≥ 5 in addition to the presence of more than one risk factor. In conclusion, patients with NLR ≥ 5 require careful monitoring and management of cardiovascular risk factors because they increase mortality when associated with progressive levels of NLR. (© 2024. The Author(s).) |
Databáze: | MEDLINE |
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