Characterizing the role of the microbiota-gut-brain axis in cerebral small vessel disease: An integrative multi‑omics study.

Autor: Song Y; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China; Research Center of Clinical Medical Imaging, Anhui Province, Hefei 230032, PR China; Anhui Provincial Institute of Translational Medicine, Hefei 230032, PR China; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei 230032, PR China., Zhou X; Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China., Zhao H; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China; Research Center of Clinical Medical Imaging, Anhui Province, Hefei 230032, PR China; Anhui Provincial Institute of Translational Medicine, Hefei 230032, PR China; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei 230032, PR China., Zhao W; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China; Research Center of Clinical Medical Imaging, Anhui Province, Hefei 230032, PR China; Anhui Provincial Institute of Translational Medicine, Hefei 230032, PR China; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei 230032, PR China., Sun Z; Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China. Electronic address: sunzhwu@126.com., Zhu J; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China; Research Center of Clinical Medical Imaging, Anhui Province, Hefei 230032, PR China; Anhui Provincial Institute of Translational Medicine, Hefei 230032, PR China; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei 230032, PR China. Electronic address: zhujiajiagraduate@163.com., Yu Y; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China; Research Center of Clinical Medical Imaging, Anhui Province, Hefei 230032, PR China; Anhui Provincial Institute of Translational Medicine, Hefei 230032, PR China; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei 230032, PR China. Electronic address: cjr.yuyongqiang@vip.163.com.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2024 Dec 01; Vol. 303, pp. 120918. Date of Electronic Publication: 2024 Nov 05.
DOI: 10.1016/j.neuroimage.2024.120918
Abstrakt: Background: Prior efforts have revealed changes in gut microbiome, circulating metabolome, and multimodal neuroimaging features in cerebral small vessel disease (CSVD). However, there is a paucity of research integrating the multi-omic information to characterize the role of the microbiota-gut-brain axis in CSVD.
Methods: We collected gut microbiome, fecal and blood metabolome, multimodal magnetic resonance imaging data from 37 CSVD patients with white matter hyperintensities and 46 healthy controls. Between-group comparison was performed to identify the differential gut microbial taxa, followed by performance of multi-stage microbiome-metabolome-neuroimaging-neuropsychology correlation analyses in CSVD patients.
Results: Our data showed both depleted and enriched gut microbes in CSVD patients. Among the differential microbes, Haemophilus and Akkermansia were associated with a range of metabolites enriched for Aminoacyl-tRNA biosynthesis pathway. Furthermore, the affected metabolites were associated with neuroimaging measures involving gray matter morphology, spontaneous intrinsic brain activity, white matter integrity, and global structural network topology, which were in turn related to cognition and emotion in CSVD patients.
Conclusion: Our findings provide an integrative framework to understand the pathophysiological mechanisms underlying the interplay between gut microbiota dysbiosis and CSVD, highlighting the potential of targeting the microbiota-gut-brain axis as a therapeutic strategy in CSVD patients.
Competing Interests: Declaration of competing interest The authors declare no conflict of interests.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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