Placental epigenetic signatures of maternal distress in glucocorticoid-related genes and newborn outcomes: A study of Spanish primiparous women.
Autor: | Castro-Quintas A; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain; Health Institut Carlos III, Network Centre for Biomedical Research in Mental Health (CIBER of Mental Health, CIBERSAM), Madrid, Spain., Palma-Gudiel H; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain; Health Institut Carlos III, Network Centre for Biomedical Research in Mental Health (CIBER of Mental Health, CIBERSAM), Madrid, Spain., Eixarch E; Department of Surgery and Surgical specializations, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain; Health Institut Carlos III, Network Centre for Biomedical Research on Rare Diseases (CIBER of Rare Diseases, CIBERER), Madrid, Spain., San Martín González N; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain; Health Institut Carlos III, Network Centre for Biomedical Research in Mental Health (CIBER of Mental Health, CIBERSAM), Madrid, Spain., Röh S; Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany., Sauer S; Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany., Rex-Haffner M; Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany., Monteserin-Garcia JL; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain; Health Institut Carlos III, Network Centre for Biomedical Research in Mental Health (CIBER of Mental Health, CIBERSAM), Madrid, Spain., de la Fuente-Tomás L; Health Institut Carlos III, Network Centre for Biomedical Research in Mental Health (CIBER of Mental Health, CIBERSAM), Madrid, Spain; Department of Psychology, University of Oviedo, Oviedo, Spain., Crispi F; Department of Surgery and Surgical specializations, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain; Health Institut Carlos III, Network Centre for Biomedical Research on Rare Diseases (CIBER of Rare Diseases, CIBERER), Madrid, Spain., Garcia Portilla MP; Health Institut Carlos III, Network Centre for Biomedical Research in Mental Health (CIBER of Mental Health, CIBERSAM), Madrid, Spain; Department of Psychiatry, University of Oviedo, Oviedo, Spain; Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain., Binder EB; Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany., Fañanas L; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain; Health Institut Carlos III, Network Centre for Biomedical Research in Mental Health (CIBER of Mental Health, CIBERSAM), Madrid, Spain. Electronic address: lfananas@ub.edu. |
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Jazyk: | angličtina |
Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2025 Jan; Vol. 90, pp. 36-47. Date of Electronic Publication: 2024 Nov 06. |
DOI: | 10.1016/j.euroneuro.2024.10.001 |
Abstrakt: | Maternal stress during pregnancy can impact offspring health, increasing the risk of neuropsychiatric disorders. The human placenta plays a crucial role in understanding this effect, influencing fetal programming as it connects maternal and fetal circulation. Our hypothesis centers on maternal stress influencing children's outcomes through placental DNA methylation, targeting three cortisol-regulating genes: NR3C1, FKBP5, and HSD11B2. In this pilot study, chorionic villi and maternal decidua placental layers from 45 mother-infant dyads (divided into two groups based on high/low maternal stress exposure) were analyzed for DNA methylation at the genes of interest via targeted bisulfite sequencing. Pregnant women provided four saliva samples throughout a day for cortisol determinations and were assessed for the presence of depressive symptoms at each of the three trimesters of pregnancy. Newborns underwent neurodevelopmental assessments and salivary cortisol evaluations at 7 weeks. Increased maternal diurnal cortisol levels in the first trimester of pregnancy was significantly associated with elevated DNA methylation at exon 1D of the NR3C1 gene and lower DNA methylation at intron 7 of the FKBP5 gene, both in chorionic villi samples. Elevated DNA methylation at introns 1 and 7 of FKBP5 in the maternal decidua were strongly linked to an anticipated delivery. DNA methylation at the HSD11B2 promoter region was uniformly low across all placental samples. No associations with newborn neurodevelopment were found. These results emphasize the importance of exploring layer-specific methylation differences at distinct pregnancy stages, highlighting the complex interplay between maternal stress, placental epigenetic modifications, and fetal development throughout the prenatal period. Competing Interests: Declaration of competing interest The authors declare that they have no competing interests. (Copyright © 2024. Published by Elsevier B.V.) |
Databáze: | MEDLINE |
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