A normative framework dissociates need and motivation in hypothalamic neurons.

Autor: Kim KS; Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea., Lee YH; Department of Anatomy and Cell Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.; Neuroscience Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea., Yun JW; Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.; Center of Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon 16419, Republic of Korea., Kim YB; Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea., Song HY; Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea., Park JS; Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea., Jung SH; Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea., Sohn JW; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea., Kim KW; Division of Physiology, Departments of Oral Biology and Applied Life Science, BK21 FOUR, Yonsei University College of Dentistry, Seoul, Korea., Kim HR; Center of Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon 16419, Republic of Korea.; Department of Biomedical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea., Choi HJ; Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.; Department of Anatomy and Cell Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.; Neuroscience Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.; Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea.; Wide River Institute of Immunology, Seoul National University, 101 Dabyeonbat-gil, Hwachon-myeon, Gangwon-do 25159, Republic of Korea.
Jazyk: angličtina
Zdroj: Science advances [Sci Adv] 2024 Nov 08; Vol. 10 (45), pp. eado1820. Date of Electronic Publication: 2024 Nov 06.
DOI: 10.1126/sciadv.ado1820
Abstrakt: Physiological needs evoke motivational drives that produce natural behaviors for survival. In previous studies, the temporally intertwined dynamics of need and motivation have made it challenging to differentiate these two components. On the basis of classic homeostatic theories, we established a normative framework to derive computational models for need-encoding and motivation-encoding neurons. By combining the model-based predictions and naturalistic experimental paradigms, we demonstrated that agouti-related peptide (AgRP) and lateral hypothalamic leptin receptor (LH LepR) neuronal activities encode need and motivation, respectively. Our model further explains the difference in the dynamics of appetitive behaviors induced by optogenetic stimulation of AgRP or LH LepR neurons. Our study provides a normative modeling framework that explains how hypothalamic neurons separately encode need and motivation in the mammalian brain.
Databáze: MEDLINE
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