Influence of maternal hyperglycemia on placental capillary distribution.

Autor:	Moreli JB; Department of Gynecology and Obstetrics, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista 'Júlio de Mesquita Filho, Botucatu, SP, Brazil.; Faculdade Ceres - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil., Ferrari N; Faculdade Ceres - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil., Ruocco AMC; Department of Gynecology and Obstetrics, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista 'Júlio de Mesquita Filho, Botucatu, SP, Brazil., Santos MGO; Faculdade Ceres - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil., Lorenzon AR; Huntington Medicina Reprodutiva-Eugin Group, São Paulo, SP, Brazil., Carlos CP; Huntington Medicina Reprodutiva-Eugin Group, São Paulo, SP, Brazil., Rudge MVC; Department of Gynecology and Obstetrics, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista 'Júlio de Mesquita Filho, Botucatu, SP, Brazil., Calderon IMP; Department of Gynecology and Obstetrics, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista 'Júlio de Mesquita Filho, Botucatu, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2024 Nov 04; Vol. 22, pp. eAO0583. Date of Electronic Publication: 2024 Nov 04 (Print Publication: 2024).
DOI:	10.31744/einstein_journal/2024AO0583
Abstrakt:	Objective: This study was conducted to investigate the distribution of placental villous vessels in pregnant women with different degrees of hyperglycemia. Methods: A cross-sectional study was performed using placental samples from 30 pregnant women without diabetes (n=10), with gestational diabetes mellitus (n=10), and with previous diabetes (type 1 and type 2 diabetes; n=10). Maternal glycemic control was evaluated using the glycemic mean and glycated hemoglobin levels. Placental samples were obtained during elective cesarean sections and processed for villous vessel analysis using immunohistochemistry for Von Willebrand factor. Vessels within 10μm of the villus margin were classified as peripheral, and vessels at a distance greater than 10μm were classified as central. The number, area, and perimeter of all vessels were evaluated, and the relationship between vessel area and total area of placental villus was calculated. Results: Pregnant women with gestational diabetes mellitus and those with previous diabetes had higher glycated hemoglobin levels. The number of vessels was reduced in the villi of the previous Diabetes Group owing to peripheral reduction. Additionally, the area, perimeter, and percentage of peripheral blood were lower in the previous Diabetes Group than in the Non-Diabetic Group. Conclusion: Maternal glycemic levels can modify placental capillary distribution.
Databáze:	MEDLINE
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