Flavonoids as Chemosensitizers in Leukemias.

Autor:	Huseynova N; Department of Biophysics and Biochemistry, Baku State University, Baku, Azerbaijan.; Department of Natural Sciences, Western Caspian University, Baku, Azerbaijan., Çetinkaya M; Department of Molecular Biology and Genetics, Laboratory of Cancer Genetics, İzmir Institute of Technology, İzmir, Turkey., Baran Z; Department of Pharmacology, Laboratory of Molecular Pharmacology, Anadolu University, Eskişehir, Turkey., Khalilov R; Department of Biophysics and Biochemistry, Baku State University, Baku, Azerbaijan., Mammadova A; Department of Botany and Plant Physiology, Baku State University, Baku, Azerbaijan., Baran Y; Department of Molecular Biology and Genetics, Laboratory of Cancer Genetics, İzmir Institute of Technology, İzmir, Turkey. yusufbaran@iyte.edu.tr.
Jazyk:	angličtina
Zdroj:	Advances in experimental medicine and biology [Adv Exp Med Biol] 2024 Nov 07. Date of Electronic Publication: 2024 Nov 07.
DOI:	10.1007/5584_2024_828
Abstrakt:	Flavonoids, a diverse group of natural compounds abundant in plants, fruits, and seeds, are not only responsible for the vibrant colors, fragrances, and flavors found in nature but also possess significant health benefits. Representing a secondary metabolite, these phytonutrients contribute to overall well-being. They have garnered considerable interest due to their diverse biological roles, encompassing antioxidant, anti-inflammatory, and anticancer properties. Flavonoids exert anticancer properties by interfering with different signaling pathways and molecules. Also, they have been demonstrated to exert chemosensitization features, where flavonoids may enhance the effectiveness of chemotherapy, and hold promise for improving cancer treatment outcomes as they have been discovered to make cancer cells more responsive to treatment. Understanding their influence on the regulation of cellular signaling provides a foundation for exploring their potential in combination with different chemotherapy agents and their possible single use for cancer treatment. Besides, they are believed to present a cost-effective approach to cancer therapeutics with possible implications for reducing the side effects of the current chemotherapy regimens, which can be a great therapeutic strategy for treating cancer types, including leukemia. This chapter explores potential approaches for creating anticancer treatments, focusing on leukemia, through integrating flavonoid nutraceuticals with traditional chemotherapy agents. (© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
Databáze:	MEDLINE
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