Epicardial Adipocytes in Cardiac Pathology and Healing.

Autor: La V; Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766-1854, USA., Nair V; Department of Molecular, Cell, & Developmental Biology, University of California, Los Angeles, CA, 90095, USA., Sunny S; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Benharash P; Division of Cardiac Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA., Thankam FG; Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766-1854, USA. Fthankam@westernu.edu.
Jazyk: angličtina
Zdroj: Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2024 Nov 06. Date of Electronic Publication: 2024 Nov 06.
DOI: 10.1007/s10557-024-07637-2
Abstrakt: Implications of epicardial adipose tissue (EAT) on the development of coronary artery disease (CAD) have garnered recent attention. Located between the myocardium and visceral pericardium, EAT possesses unique morphological and physiological contiguity to the heart. The transcriptome and secretome of EAT differ from that of other fat stores in the body. Physiologically, EAT protects the adjacent myocardium through its brown-fat-like thermogenic function and rapid fatty acid oxidation. However, EAT releases pro-inflammatory mediators acting on the myocardium and coronary vessels, thus contributing to the development and progression of cardiovascular diseases (CVD). Furthermore, EAT-derived mesenchymal stromal cells indicate promising regenerative capabilities that offer novel opportunities in cell-based cardiac regeneration. This review aims to provide a comprehensive understanding and unraveling of EAT mechanisms implicated in regulating cardiac function and regeneration under pathological conditions. A holistic understanding of the multifaceted nature of EAT is essential to the future development of pharmacological and therapeutic interventions for the management of CVD.
(© 2024. The Author(s).)
Databáze: MEDLINE
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