Developmental encoding of natural sounds in the mouse auditory cortex.

Autor:	Zucca S; Department of Life Sciences and Systems Biology (DBIOS), University of Turin, via Accademia Albertina 13, 10123 Turin, Italy.; Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Regione Gonzole 10, 10143 Orbassano, Italy., La Rosa C; Department of Life Sciences and Systems Biology (DBIOS), University of Turin, via Accademia Albertina 13, 10123 Turin, Italy.; Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Regione Gonzole 10, 10143 Orbassano, Italy., Fellin T; Optical Approaches to Brain Function Laboratory, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genoa, Italy., Peretto P; Department of Life Sciences and Systems Biology (DBIOS), University of Turin, via Accademia Albertina 13, 10123 Turin, Italy.; Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Regione Gonzole 10, 10143 Orbassano, Italy., Bovetti S; Department of Life Sciences and Systems Biology (DBIOS), University of Turin, via Accademia Albertina 13, 10123 Turin, Italy.; Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Regione Gonzole 10, 10143 Orbassano, Italy.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 Nov 05; Vol. 34 (11).
DOI:	10.1093/cercor/bhae438
Abstrakt:	Mice communicate through high-frequency ultrasonic vocalizations, which are crucial for social interactions such as courtship and aggression. Although ultrasonic vocalization representation has been found in adult brain areas along the auditory pathway, including the auditory cortex, no evidence is available on the neuronal representation of ultrasonic vocalizations early in life. Using in vivo two-photon calcium imaging, we analyzed auditory cortex layer 2/3 neuronal responses to USVs, pure tones (4 to 90 kHz), and high-frequency modulated sweeps from postnatal day 12 (P12) to P21. We found that ACx neurons are tuned to respond to ultrasonic vocalization syllables as early as P12 to P13, with an increasing number of responsive cells as the mouse age. By P14, while pure tone responses showed a frequency preference, no syllable preference was observed. Additionally, at P14, USVs, pure tones, and modulated sweeps activate clusters of largely nonoverlapping responsive neurons. Finally, we show that while cell correlation decreases with increasing processing of peripheral auditory stimuli, neurons responding to the same stimulus maintain highly correlated spontaneous activity after circuits have attained mature organization, forming neuronal subnetworks sharing similar functional properties. (© The Author(s) 2024. Published by Oxford University Press.)
Databáze:	MEDLINE
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