NK Cell-Based Cancer Immunotherapies: Current Progress, Challenges and Emerging Opportunities.

Autor: Alshahrani MY; Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia., Uthirapathy S; Pharmacy Department, Faculty of Pharmacy, Tishk International University, Erbil, Kurdistan Region, Iraq., Kumar A; Department of Nuclear and Renewable Energy, Ural Federal University Named after the First President of Russia Boris Yeltsin, Ekaterinburg, Russia.; Department of Technical Sciences, Western Caspian University, Baku, Azerbaijan.; Department of Mechanical Engineering, Karpagam Academy of Higher Education, Coimbatore, India., Oghenemaro EF; Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Delta State University, Abraka, Delta State, Nigeria., R R; Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, India., Lal M; Department of Medicine, National Institute of Medical Sciences, NIMS University, Rajasthan, Jaipur, India., Arora I; Chandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Mohali, Punjab, India., Chauhan AS; Uttaranchal Institute of Pharmaceutical Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, Uttarakhand, India., Saud MJ; Al-Hadi University College, Baghdad, Iraq., Hulail HM; Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
Jazyk: angličtina
Zdroj: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2024 Nov; Vol. 38 (11), pp. e70044.
DOI: 10.1002/jbt.70044
Abstrakt: Natural killer (NK) cells are vital innate immune cells that play a crucial role in cancer therapy. They are targeted by therapies designed to modulate, retain, and enhance their antitumor function in vivo. In addition to whole-cell therapy, NK cell-derived exosomes (NDEs) offer high immune safety and are easily subject to chemical, biological, and immunological modifications. This makes them suitable for use in combination with various current cancer therapies to enhance efficacy, treatment outcomes, and reduce side effects in vivo. This review aims to outline summarizes the antitumor potential of NK cells, as well as the current challenges and opportunities in NK cell-based immunotherapies such as allogeneic and autologous NK cell transplantation, CAR NK cell therapy, and the use of cytokines and monoclonal antibodies. The review also explores the dual regulatory effects of tumor exosomes on NK cells, and highlights the potential of NDEs, either alone or in combination with other antitumor therapies, to reprogram the immunosuppressive tumor microenvironment and expedite the therapeutic effects of cancer immunotherapy in future clinical research.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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