Idiopathic acute pancreatitis (IAP)-a review of the literature and algorithm proposed for the diagnostic work-up of IAP.

Autor:	Aronen A; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Guilabert L; Gastroenterology Department, Dr. Balmis General University Hospital, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain., Hadi A; Pancreatitis Centre East, Gastrounit, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Copenhagen, Denmark., Kiudelis V; Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania., Panaitescu A; Gastroenterology and Interventional Endoscopy Department, Bucharest Clinical Emergency Hospital, Bucharest, Romania., Wlodarczyk B; Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland., Laukkarinen J; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Regner S; Surgery Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Department of Surgery and Gastroenterology, Skåne University Hospital, Malmö, Sweden., de-Madaria E; Gastroenterology Department, Dr. Balmis General University Hospital, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain.
Jazyk:	angličtina
Zdroj:	Translational gastroenterology and hepatology [Transl Gastroenterol Hepatol] 2024 Sep 13; Vol. 9, pp. 71. Date of Electronic Publication: 2024 Sep 13 (Print Publication: 2024).
DOI:	10.21037/tgh-23-125
Abstrakt:	Background and Objective: This narrative review addresses idiopathic acute pancreatitis (IAP) and its epidemiology, diagnosis, clinical course and treatment during the last decade. As there is no previously validated protocol for finding the aetiology of acute pancreatitis (AP), the primary aim of this study is to find, describe and unify evidence about the diagnostic work-up of AP to diagnose the true IAP. By finding the aetiology with the highest possible yield it may be possible to reduce recurrent AP (RAP) episodes and related morbidity and thereby decrease health care costs and possibly improve patients' quality of life. Methods: This narrative review includes articles retrieved from PubMed search with publications from 2013-2023. Cross references were used when found relevant. Key Content and Findings: The rates of aetiologies of AP and the diagnostics performed behind these numbers vary widely between different studies, time periods and different geographical regions, as there is no unified algorithm in diagnostic work-up of IAP. In this study, we describe an up-to-date summary of epidemiology, diagnostic course and treatment of IAP, and propose an algorithm of IAP diagnostics in light of recent scientific studies and their outcomes and address possible treatments of IAP. Conclusions: Although aetiology is key for AP management, there is still no validated protocol for aetiological diagnosis. IAP is relevant due to its recurrence rate and possible evolution to chronic pancreatitis. We still need more studies addressing this topic and evaluating new diagnostic protocols with advanced tests and treatment strategies in true IAP. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tgh.amegroups.com/article/view/10.21037/tgh-23-125/coif). L.G. received a grant from the Spanish Gastroenterology Association, not related to this paper. S.R. received a Swedish Government Grant for Clinical Research (ALF), Region Skåne Regional Research Grants, and support from the Einar and Inga Nilsson Foundation. She has royalties/licenses with Studentlitteratur, Lund, Sweden, and has received honoraria as a speaker from Viatris. Enrique de-Madaria has received two grants from Abbott and Viatris. Janssen, Abbott, and Viatris have paid him honoraria as a speaker, and Janssen has supported his attendance at meetings and travel expenses. He has also served on an advisory board with Medpace. The other authors have no conflicts of interest to declare. (2024 AME Publishing Company. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu