Accelerated epigenetic aging and prospective morbidity and mortality among U.S. veterans.

Autor:	Bourassa KJ; VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System.; Department of Psychology, Georgetown University.; Geriatric Research, Education, and Clinical Center, Durham VA Health Care System.; Center for the Study of Aging and Human Development, Duke University Medical Center., Anderson L; VA Health Services Research and Development Center of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Health Care System., Woolson S; VA Health Services Research and Development Center of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Health Care System., Dennis PA; VA Health Services Research and Development Center of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Health Care System.; Department of Population Health Sciences, Duke University Medical Center., Garrett ME; Duke Molecular Physiology Institute, Duke University., Hair L; VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine., Dennis M; VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine., Sugden K; Department of Psychology and Neuroscience, Duke University., Williams B; Department of Psychology and Neuroscience, Duke University., Houts R; Department of Psychology and Neuroscience, Duke University., Calhoun PS; VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System.; VA Health Services Research and Development Center of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Health Care System.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine., Naylor JC; VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine., Ashley-Koch AE; Duke Molecular Physiology Institute, Duke University., Beckham JC; VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine., Caspi A; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine.; Department of Psychology and Neuroscience, Duke University.; Institute of Psychiatry, Psychology and Neuroscience, King's College London.; Center for the Study of Population Health & Aging, Duke University Population Research Institute., Taylor GA; Geriatric Research, Education, and Clinical Center, Durham VA Health Care System.; Center for the Study of Aging and Human Development, Duke University Medical Center.; Department of Medicine, Duke University.; Department of Integrative Immunobiology, Duke University Medical Center., Hall KS; Geriatric Research, Education, and Clinical Center, Durham VA Health Care System.; Center for the Study of Aging and Human Development, Duke University Medical Center.; Department of Medicine, Duke University., Moffitt TE; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine.; Department of Psychology and Neuroscience, Duke University.; Institute of Psychiatry, Psychology and Neuroscience, King's College London.; Center for the Study of Population Health & Aging, Duke University Population Research Institute., Kimbrel NA; VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System.; VA Health Services Research and Development Center of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Health Care System.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 Oct 23. Date of Electronic Publication: 2024 Oct 23.
DOI:	10.1101/2024.10.23.24315691
Abstrakt:	Epigenetic measures of aging derived from DNA methylation are promising biomarkers associated with prospective morbidity and mortality, but require validation in real-world medical settings. Using data from 2,216 post-9/11 veterans, we examined whether accelerated DunedinPACE aging scores were associated with chronic disease morbidity, predicted healthcare costs, and mortality assessed over an average of 13.1 years of follow up in VA electronic health records. Veterans with faster DunedinPACE aging scores developed more chronic disease and showed larger increases in predicted healthcare costs over the subsequent 5, 10, and 15 years. Faster aging was associated with incident myocardial infarction, stroke, diabetes, cancer, liver disease, and renal disease, as well greater risk of mortality due to all-causes and chronic disease. These findings provide evidence that accelerated epigenetic aging is associated with worsening prospective health across multiple chronic diseases and organ systems assessed using electronic health records from an integrated healthcare system. Competing Interests: Conflicts of interest: Drs. Terrie Moffitt, Avshalom Caspi, and Karen Sugden are named as an inventor on a license issued by Duke University for the DunedinPACE. The algorithm to calculate DunedinPACE is publicly available on Github, https://github.com/danbelsky/DunedinPACE. No other authors have conflicts of interest to report.
Databáze:	MEDLINE
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