The role of the microbiota in respiratory virus-bacterial pathobiont relationships in the upper respiratory tract.

Autor:	Kelly MS; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana.; Division of Pediatric Infectious Diseases, Duke University, Durham, North Carolina, United States.; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States., Shi P; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, United States., Boiditswe SC; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana., Qin E; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, United States., Steenhoff AP; Botswana-University of Pennsylvania Partnership, Gaborone, Botswana.; Global Health Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.; Division of Pediatric Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States., Mazhani T; University of Botswana School of Medicine, Gaborone, Botswana., Patel MZ; University of Botswana School of Medicine, Gaborone, Botswana., Cunningham CK; Division of Pediatric Infectious Diseases, University of California, Irvine, Children's Hospital of Orange County, Orange, California, United States., Rawls JF; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States., Luinstra K; Infectious Disease Research Group, Research Institute of St. Joe's Hamilton, Hamilton, Ontario, Canada., Gilchrist J; Infectious Disease Research Group, Research Institute of St. Joe's Hamilton, Hamilton, Ontario, Canada., Maciejewski J; Infectious Disease Research Group, Research Institute of St. Joe's Hamilton, Hamilton, Ontario, Canada., Hurst JH; Division of Pediatric Infectious Diseases, Duke University, Durham, North Carolina, United States., Seed PC; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Bulir D; Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada., Smieja M; Infectious Disease Research Group, Research Institute of St. Joe's Hamilton, Hamilton, Ontario, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 Oct 23. Date of Electronic Publication: 2024 Oct 23.
DOI:	10.1101/2024.10.22.24315478
Abstrakt:	The mechanisms by which respiratory viruses predispose to secondary bacterial infections remain poorly characterized. Using 2,409 nasopharyngeal swabs from 300 infants in Botswana, we performed a detailed analysis of factors that influence the dynamics of bacterial pathobiont colonization during infancy. We quantify the extent to which viruses increase the acquisition of Haemophilus influenzae , Moraxella catarrhalis , and Streptococcus pneumoniae . We provide evidence of cooperative interactions between these pathobionts while identifying host characteristics and environmental exposures that influence the odds of pathobiont colonization during early life. Using 16S rRNA gene sequencing, we demonstrate that respiratory viruses result in losses of putatively beneficial Corynebacterium and Streptococcus species that are associated with a lower odds of pathobiont acquisition. These findings provide novel insights into viral-bacterial relationships in the URT of direct relevance to respiratory infections and suggest that the URT bacterial microbiota is a potentially modifiable mechanism by which viruses promote bacterial respiratory infections. Competing Interests: Competing interests: MSK is a consultant for Merck & Co, Inc. and Invivyd. All other authors declare that they have no competing interests.
Databáze:	MEDLINE
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