Characterization and Performance Evaluation of Magnesium Chloride-Enriched Polyurethane Nanofiber Patches for Wound Dressings.

Autor:	Mani MP; Department of Mechanical Engineering, SNS College of Technology, Coimbatore, TN, India.; School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai, JB, Malaysia., Ponnambalath Mohanadas H; Device Development Group, New Product Research and Development, Abbott Diabetes Care, Alameda, CA, USA., Mohd Faudzi AA; School of Electrical Engineering, Faculty of Engineering, UniversitiTeknologi Malaysia, Skudai, JB, Malaysia.; Centre for Artificial Intelligence and Robotics, Universiti Teknologi Malaysia, Kuala Lumpur, SG, Malaysia., Ismail AF; Advanced Membrane Technology Research Centre (AMTEC), School of Chemical and Energy Engineering, Universiti Teknologi Malaysia, Skudai, JB, Malaysia., Tucker N; School of Engineering and Physical Sciences, College of Health and Sciences, University of Lincoln, Lincoln, LS, UK., Mohamaddan S; Innovative Global ProgramCollege of Engineering Shibaura Institute of Technology Tokyo, Tokyo, Japan., Ayyar M; Department of Chemistry, Centre for Materials Chemistry, Karapagam Acdemy of Higher Education, Coimbatore, TN, India., Palanisamy T; Department of Mechanical Engineering, SNS College of Technology, Coimbatore, TN, India., Rathanasamy R; Department of Mechanical Engineering, Kongu Engineering College, Perunduari, TN, India., Jaganathan SK; Institute of Research and Development, Duy Tan University, Da Nang, Vietnam.; School of Engineering & Technology, Duy Tan University, Da Nang, Vietnam.; Biomaterials and Tissue Engineering, School of Engineering and Physical Sciences, College of Health and Sciences, University of Lincoln, Lincoln, LS, UK.
Jazyk:	angličtina
Zdroj:	International journal of nanomedicine [Int J Nanomedicine] 2024 Nov 01; Vol. 19, pp. 11129-11141. Date of Electronic Publication: 2024 Nov 01 (Print Publication: 2024).
DOI:	10.2147/IJN.S460921
Abstrakt:	Purpose: Wound patches are essential for wound healing, yet developing patches with enhanced mechanical and biological properties remains challenging. This study aimed to enhance the mechanical and biological properties of polyurethane (PU) by incorporating magnesium chloride (MgCl 2 ) into the patch. Methodology: The composite patch was fabricated using the electrospinning technique, producing nanofibers from a mixture of PU and MgCl 2 solutions. The electrospun PU/MgCl 2 was then evaluated for various physico-chemical characteristics and biological properties to determine its suitability for wound healing applications. Results: Tensile strength testing showed that the mechanical properties of the composite patch (10.98 ± 0.18) were significantly improved compared to pristine PU (6.66 ± 0.44). Field scanning electron microscopy (FESEM) revealed that the electrospun nanofiber patch had a smooth, randomly oriented non-woven structure (PU - 830 ± 145 nm and PU/MgCl 2 - 508 ± 151 nm). Fourier infrared spectroscopy (FTIR) confirmed magnesium chloride's presence in the polyurethane matrix via strong hydrogen bond formation. Blood compatibility studies using coagulation assays, including activated partial thromboplastin time (APTT), prothrombin time (PT), and hemolysis assays, demonstrated improved blood compatibility of the composite patch (APTT - 174 ± 0.5 s, PT - 91 ± 0.8s, and Hemolytic percentage - 1.78%) compared to pristine PU (APTT - 152 ± 1.2s, PT - 73 ± 1.7s, and Hemolytic percentage - 2.55%). Antimicrobial testing showed an enhanced zone of inhibition (Staphylococcus aureus - 21.5 ± 0.5 mm and Escherichia coli - 27.5 ± 2.5 mm) compared to the control, while cell viability assays confirmed the non-cytotoxic nature of the developed patches on fibroblast cells. Conclusion: The study concludes that adding MgCl 2 to PU significantly improves the mechanical, biological, and biocompatibility properties of the patch. This composite patch shows potential for future wound healing applications, with further studies needed to validate its efficacy in-vivo. Competing Interests: The authors report no conflicts of interest in this work. (© 2024 Mani et al.)
Databáze:	MEDLINE
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