The underestimated role of major skin commensal Malassezia furfur in the development of neonatal invasive fungal infections.

Autor:	Priputnevich TV; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russia, Russia., Gordeev AB; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russia, Russia., Shabanova NE; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russia, Russia., Denisov P; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russia, Russia., Trofimov DY; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russia, Russia., Balashova EN; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russia, Russia., Donnikov AE; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russia, Russia., Yarotskaya EL; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russia, Russia., Zubkov VV; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russia, Russia., Sukhikh GT; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russia, Russia.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2024 Oct 01; Vol. 10 (20), pp. e38767. Date of Electronic Publication: 2024 Oct 01 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2024.e38767
Abstrakt:	In recent years, some new evidence on the role of Malassezia in late-onset sepsis in immunocompromised patients have been published, but there are still very few studies with special focus on newborns. The prevalence of Malassezia -associated conditions in 3519 newborn patients of general and surgical neonatal intensive care units (NICU) was assessed. All patients underwent pharyngeal and rectal swab screening for Malassezia spp. Identification of Malassezia spp. was carried out with the use of an adapted nutrient media, microscopic assessment of yeast cell morphology, and real-time PCR analysis. Malassezia furfur -induced invasive mycoses (IM) were developed 2.5 times more often in very low birth weight (VLBW) M. furfur -positive newborns, than in neonates with birth weight ≥1500 g, and affecting 15.8 % of VLBW infants. Funguria occurred 16 times more often in VLBW babies, but fungemia incidence was similar for both weight categories. Gastrointestinal (GI) colonization was found in 94.6 % of Malassezia -positive population, and in 8 % of all studied neonates. Among IM patients, death rate was 6.5 %. The specific pathogen was highly detectable by a combination of real-time PCR and an adapted nutrient media. Colonization with M. furfur in newborns was associated with low gestational age, VLBW, and long stay in NICU. The findings emphasize the need to monitor colonization and infection with M. furfur in neonates, staying in ICU for more than two weeks and to improve current diagnostic approaches by using real-time PCR and an adapted nutrient media for M. furfur isolation. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The data were presented at international conferences, including Priputnevich T.V. "Congress of the International Society of Human and Animal Mycology", Amsterdam, 2018 with the report "Morbidity of fungal infections caused by Malassezia furfur in neonatal intensive care units". I would like to comment on the data and its storage. Our center's servers store all patient information. With the help of special software developed by us, we can analyze almost all patients and provide this information upon request. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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