Aggressive Pediatric Primitive Round Cell Tumors with MN1::ZNF341 Fusion: A Mimic of Neuroblastoma.

Autor: Tan SY; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA., Evans MG; Caris Life Sciences, Phoenix, Arizona, USA., Saab R; Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA., Gupta A; Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA., Reid J; Department of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange, California, USA., Dao T; Department of Radiology, Children's Hospital of Orange County, Orange, California, USA., Rubin E; Department of Oncology, Children's Hospital of Orange County, Orange, California, USA., Crymes A; Department of Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA., Semenova K; Department of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange, California, USA., Shimada H; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA., Livasy C; Department of Pathology, Atrium Health, Charlotte, North Carolina, USA., Nael A; Department of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange, California, USA.; Department of Pathology and Laboratory Medicine, Children's Hospital of Orange County, Orange, California, USA.
Jazyk: angličtina
Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2025 Jan; Vol. 72 (1), pp. e31425. Date of Electronic Publication: 2024 Nov 06.
DOI: 10.1002/pbc.31425
Abstrakt: Neuroblastoma is one of the most common tumors in young children, arising from the adrenal medulla or paraspinal sympathetic ganglia. We describe primitive round cell tumors presenting in three patients less than 1.5 years old, with striking clinical and pathologic similarities to neuroblastoma. Unlike neuroblastoma, however, these primitive tumors did not show specific histologic or immunophenotypic evidence of neuroblastic differentiation, and harbored a MN1::ZNF341 fusion. All patients progressed through neuroblastoma therapy and ultimately died of disease. These highly aggressive tumors mimicking neuroblastoma appear to be a novel and distinctive entity in need of further characterization.
(© 2024 The Author(s). Pediatric Blood & Cancer published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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