Neurocutaneous Melanocytosis-Associated Hydrocephalus: The Memorial Sloan Kettering Experience from 2001 to 2022.

Autor: Rodriguez S; Deaprtment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA., DeIeso-Frechette F; Deaprtment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Umeasor C; Deaprtment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Alli C; Deaprtment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Azzi C; Deaprtment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Haque S; Deaprtment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Deaprtment of Pediatrics, New York-Presbyterian: Weill Cornell Medical Center, New York, New York, USA., Pugh JA; Deaprtment of Pediatrics, Albany Medical Center, Albany, New York, USA., Meeker N; Deaprtment of Pediatrics, St. Luke's Children's Cancer Institute, Boise, Idaho, USA., Khakoo Y; Deaprtment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Deaprtment of Pediatrics, New York-Presbyterian: Weill Cornell Medical Center, New York, New York, USA.
Jazyk: angličtina
Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2024 Nov 06, pp. e31434. Date of Electronic Publication: 2024 Nov 06.
DOI: 10.1002/pbc.31434
Abstrakt: We report two neurocutaneous melanocytosis (NCM) patients who required ventriculoperitoneal shunt placement and subsequently developed intraperitoneal melanoma. These patients with NCM are at an increased risk for developing NRAS-associated melanomas in the central nervous system, which in turn may lead to symptomatic hydrocephalus requiring cerebrospinal fluid diversion. Due to the rarity of NCM, current knowledge on disease progression and appropriate management is limited. Ongoing studies aiming to better understand this condition and inform its clinical management may help to identify risk factors for developing more severe complications.
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Databáze: MEDLINE
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