Exploring the FAP-Targeted Therapeutics for Adrenocortical Carcinoma: Choosing the Right Track.
| Autor: | Chopra S; From the Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Walia R; Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Kaur K; From the Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Roesch F; Department of Chemistry, Johannes Gutenberg University, Mainz, Germany., Moon ES; Department of Chemistry, Johannes Gutenberg University, Mainz, Germany., Mittal BR; From the Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Shukla J; From the Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. |
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| Jazyk: | angličtina |
| Zdroj: | Clinical nuclear medicine [Clin Nucl Med] 2024 Nov 06. Date of Electronic Publication: 2024 Nov 06. |
| DOI: | 10.1097/RLU.0000000000005483 |
| Abstrakt: | Abstract: Metastatic or recurrent adrenocortical carcinoma is a potentially lethal malignancy, presenting significant challenges in disease management owing to absence of effective systemic treatments. Significantly diminished survival rates necessitate rapid identification of specific molecules for the development of targeted therapeutics. Fibroblast activation protein (FAP)-expressing cancer-associated fibroblasts have been a major breakthrough causing a paradigm shift in targeted theranostics focusing on the tumor microenvironment. The effectiveness of various FAP inhibitors (FAPis) and FAP targeting peptide has been extensively documented in diverse clinical investigations. We have evaluated 3 molecules, that is, DOTA.SA.FAPi (SA.FAPi), FAPi46, and FAP2286, as potential theranostic probes for adrenocortical carcinoma. Competing Interests: Conflicts of interest and sources of funding: none declared. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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