Pulmonary diffusing capacity among individuals recovering from mild to moderate COVID-19: a cross-sectional study.

Autor: Yelin D; Infectious Diseases Unit, Sheba Medical Center, Ramat Gan, Israel. dana.yelin@gmail.com.; Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. dana.yelin@gmail.com., Ghantous N; Department of Internal Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel., Awwad M; Department of Internal Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel., Daitch V; Research Authority, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel., Kalfon T; Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel., Mor M; Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel., Buchrits S; Department of Internal Medicine A, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel., Shafir Y; Department of Internal Medicine F, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel., Shapira-Lichter I; Functional MRI Center, Sagol School of Neuroscience, Rabin Medical Center, Beilinson Hospital, Tel Aviv University, Petah Tikva, Ramat Aviv, Tel Aviv, Israel., Leibovici L; Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.; Research Authority, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel., Yahav D; Infectious Diseases Unit, Sheba Medical Center, Ramat Gan, Israel.; Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel., Margalit I; Infectious Diseases Unit, Sheba Medical Center, Ramat Gan, Israel.; Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel., Shitenberg D; Pulmonary Institue, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.; Rabin Medical Center, COVID Recovery Clinic, Beilinson Hospital, Petah Tikva, Israel.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 05; Vol. 14 (1), pp. 26767. Date of Electronic Publication: 2024 Nov 05.
DOI: 10.1038/s41598-024-74404-6
Abstrakt: Impaired pulmonary diffusing capacity for carbon monoxide (DLCO) following COVID-19 has been consistently reported among individuals recovering from severe-critical infection. However, most long COVID cases follow non-severe COVID-19. We assessed DLCO among individuals with long COVID recovering from mild to moderate acute illness. A cross-sectional study of adults with long COVID, assessed at a COVID recovery clinic > 3 months following the onset of acute infection, during 2020-2021. Participants subjectively ranked their dyspnea severity based on its impact on their daily living and underwent comprehensive pulmonary function testing (PFT). Clinical correlates for impaired DLCO (defined as < 80%) were assessed using multivariable logistic regression models. A total of 458 individuals, their mean age 45 (SD 16) and 246 (54%) of whom are women, were evaluated at an average of ~ 4 months following acute COVID-19. The most frequent PFT impairment was reduced DLCO, identified among 67 (17%) of the cohort. Clinical correlates of impaired DLCO included women (odds ration [OR] 3.64, 95% confidence interval [CI] 1.78-7.45, p < 0.001), cigarette smoking (OR 2.25, 95% CI 1.14-4.43, p = 0.019), and moderate-severe dyspnea (OR 2.77, 95% CI 1.39-5.50, p = 0.004). BMI inversely correlated with DLCO (OR 0.90, 95% CI 0.85-0.96 per 1 unit, p = 0.002). Impaired DLCO was not uncommon among individuals recovering from mild to moderate COVID-19. Women are at a greater risk, and subjective dyspnea correlated with impaired DLCO. Clinicians can rely on self-reported significant dyspnea to guide further assessment.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje