A Multiparadigm Approach to Characterize Dominance Behaviors in CD1 and C57BL6 Male Mice.

Autor:	Cum M; Department of Neuroscience, University of Florida, Gainesville, Florida 32610., Santiago Pérez JA; Department of Neuroscience, University of Florida, Gainesville, Florida 32610., Iwata RL; Department of Neuroscience, University of Florida, Gainesville, Florida 32610., Lopez N; Department of Neuroscience, University of Florida, Gainesville, Florida 32610., Higgs A; Department of Neuroscience, University of Florida, Gainesville, Florida 32610., Li A; Department of Neuroscience, University of Florida, Gainesville, Florida 32610., Ye C; Department of Neuroscience, University of Florida, Gainesville, Florida 32610., Wangia E; Department of Neuroscience, University of Florida, Gainesville, Florida 32610., Wright ES; Department of Neuroscience, University of Florida, Gainesville, Florida 32610., García Restrepo C; Department of Sociology, University of Chicago, Chicago, Illinois 60637., Padilla-Coreano N; Department of Neuroscience, University of Florida, Gainesville, Florida 32610 npadillacoreano@ufl.edu.
Jazyk:	angličtina
Zdroj:	ENeuro [eNeuro] 2024 Nov 22; Vol. 11 (11). Date of Electronic Publication: 2024 Nov 22 (Print Publication: 2024).
DOI:	10.1523/ENEURO.0342-24.2024
Abstrakt:	Social status and dominance are critical factors influencing well-being and survival across multiple species. However, dominance behaviors vary widely across species, from elaborate feather displays in birds to aggression in chimps. To effectively study dominance, it is essential to clearly define and reliably measure dominance behaviors. In laboratory settings, C57BL/6 mice are commonly used to study dominance due to their stable and linear social hierarchies. However, other mouse strains are also used for laboratory research. Despite substantial evidence for strain effects on behavioral repertoires, the impact of strain on dominance in mice remains largely unstudied. To address this gap, we compared dominance behaviors between CD1 and C57BL/6 male mice across four assays: observation of agonistic behaviors, urine marking, tube test, and a reward competition. We found that CD1 mice demonstrate increased fighting, increased territorial marking through urination, and increased pushing and resisting in the tube test. We used unsupervised machine learning and pose estimation data from the reward competitions to uncover behavioral differences across strains and across rank differences between competing pairs. Of the four assays, urine marking and agonistic behaviors showed the strongest correlation with dominance in both strains. Most notably, we found that CD1 dominance rankings based on the tube test negatively correlated with rankings from all three other assays, suggesting that the tube test may measure a different behavior in CD1 mice. Our results highlight that behaviors can be strain-specific in mice and studies that measure social rank should consider assays carefully to promote reproducibility. Competing Interests: The authors declare no competing financial interests. (Copyright © 2024 Cum et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu