A review of in vitro antioxidant and antidiabetic polysaccharides: Extraction methods, physicochemical and structure-activity relationships.

Autor: Md Yusoff MH; Analytical Biochemistry Research Centre (ABrC), University Innovation Incubator (I(2)U), sains@usm Campus, Universiti Sains Malaysia, Lebuh Bukit Jambul, 11900 Bayan Lepas, Penang, Malaysia., Shafie MH; Analytical Biochemistry Research Centre (ABrC), University Innovation Incubator (I(2)U), sains@usm Campus, Universiti Sains Malaysia, Lebuh Bukit Jambul, 11900 Bayan Lepas, Penang, Malaysia. Electronic address: hakiminshafie@usm.my.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Dec; Vol. 282 (Pt 4), pp. 137143. Date of Electronic Publication: 2024 Nov 03.
DOI: 10.1016/j.ijbiomac.2024.137143
Abstrakt: Nowadays, various plant polysaccharides have been successfully extracted which exhibited strong biological activities and might be useful for diabetes management. However, the effect of extraction methods, physicochemical and the structural-activity relationships of polysaccharides to exhibit antioxidants and antidiabetics were inadequate to explain their mechanism in action. The uses of advance extraction methods might be preferred to obtain higher antioxidants and antidiabetic activities of polysaccharides compared to conventional methods, but the determination of optimal extraction conditions might be crucial to preserve their structure and biological functions. Other than that, the physicochemical and structural properties of polysaccharides were closely related to their biological activities such as antioxidant and antidiabetic activities. Therefore, this review addressed the research gap of the influence of extraction methods, physicochemical and structural relationships of polysaccharides to biological activities, pointing out the challenges and limitations as well as future prospects to the current findings.
Competing Interests: Declaration of competing interest The authors declared that they have no conflict of interest in the subject matter discussed in the manuscript.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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