On the targeting of voltage-gated calcium channels to neurotransmitter release sites.

Autor: Chin M; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Kaeser PS; Department of Neurobiology, Harvard Medical School, Boston, MA, USA. Electronic address: kaeser@hms.harvard.edu.
Jazyk: angličtina
Zdroj: Current opinion in neurobiology [Curr Opin Neurobiol] 2024 Nov 04; Vol. 89, pp. 102931. Date of Electronic Publication: 2024 Nov 04.
DOI: 10.1016/j.conb.2024.102931
Abstrakt: At the presynaptic active zone, voltage-gated Ca 2+ channels (Ca V s) mediate Ca 2+ entry for neurotransmitter release. Ca V s are a large family of proteins, and different subtypes have distinct localizations across neuronal somata, dendrites and axons. Here, we review how neurons establish and maintain a specific Ca V repertoire at their active zones. We focus on molecular determinants for cargo assembly, presynaptic delivery and release site tethering, and we discuss recent work that has identified key roles of the Ca V intracellular C-terminus. Finally, we evaluate how these mechanisms may differ between different types of neurons. Work on Ca V s provides insight into the protein targeting pathways that help maintain neuronal polarity.
Competing Interests: Declaration of competing interest The authors declare no competing interests.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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