Designing small-molecule and macromolecule sensors for imaging redox-active transition metal signaling.

Autor: Pezacki AT; Department of Chemistry, Princeton University, Princeton, NJ 08540, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA., Gao J; Department of Chemistry, Princeton University, Princeton, NJ 08540, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA., Chang CJ; Department of Chemistry, Princeton University, Princeton, NJ 08540, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. Electronic address: chrischang@princeton.edu.
Jazyk: angličtina
Zdroj: Current opinion in chemical biology [Curr Opin Chem Biol] 2024 Dec; Vol. 83, pp. 102541. Date of Electronic Publication: 2024 Nov 04.
DOI: 10.1016/j.cbpa.2024.102541
Abstrakt: Transition metals play essential roles in biology, where these nutrients regulate protein activity as active site cofactors or via metalloallostery. In contrast, dysregulation of transition metal homeostasis can lead to unique metal-dependent signaling pathways connected to aging and disease, such as cuproptosis and ferroptosis for copper- and iron-dependent cell death or cuproplasia and ferroplasia for copper- and iron-dependent cell growth and proliferation, respectively. New methods that enable detection of bioavailable transition metal pools with both metal and oxidation state specificity can help decipher their contributions to health and disease. Here we summarize recent advances in designing sensors for imaging transition metals and their applications to uncover new metal biology.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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