Impact of timing of pregnancy and genetic risk on local therapy choices for young women with breast cancer.

Autor: Lipsyc-Sharf M; University of California Los Angeles, Department of Medicine, Division of Hematology-Oncology, USA., Huang M; University of California Los Angeles, Department of Surgery, Division of Surgical Oncology, USA., Huang SY; University of California Los Angeles, Department of Surgery, Division of Surgical Oncology, USA., Suresh YK; University of California Los Angeles, Department of Surgery, Division of Surgical Oncology, USA., Doll A; University of California Los Angeles, Department of Surgery, Division of Surgical Oncology, USA., Baker JL; University of California Los Angeles, Department of Surgery, Division of Surgical Oncology, USA., Kapoor NS; University of California Los Angeles, Department of Surgery, Division of Surgical Oncology, USA. Electronic address: nskapoor@mednet.ucla.edu.
Jazyk: angličtina
Zdroj: American journal of surgery [Am J Surg] 2024 Oct 29; Vol. 239, pp. 116060. Date of Electronic Publication: 2024 Oct 29.
DOI: 10.1016/j.amjsurg.2024.116060
Abstrakt: Background: It is unknown whether timing of pregnancy before, during, or after breast cancer (BC) is associated with surgical choices in young women with breast cancer.
Methods: A retrospective chart review identified patients who had a pregnancy within 5 years prior to breast cancer diagnosis (PpBC), were pregnant during breast cancer diagnosis (PrBC), or had a pregnancy within 5 years after BC diagnosis (SPBC). Chi-square test and logistic regression analysis were used to compare surgical choice-unilateral surgery (ULS) or bilateral mastectomy (BM)-between groups.
Results: Of 109 women, 36 (33.0 ​%) had PpBC, 18 (16.5 ​%) had PrBC, and 55 (50.5 ​%) had SPBC. 42.2 ​% had stage II BC and 31.2 ​% had triple negative BC (TNBC). 100 patients had genetic testing and 30 (30 ​%) had a germline pathogenic mutation. Overall, 49.5 ​% of women underwent BM, and this was similar between groups. On logistic regression, genetic mutation (OR 5.44, p ​= ​0.003) and ER-negative tumor subtype (TNBC OR 11.9, p ​= ​0.017; ER-/HER2+ OR 23.2, p ​= ​0.015) were associated with higher rates of BM.
Conclusion: In this study, approximately half of women with pregnancy within 5 years of BC diagnosis underwent BM. Genetic predisposition and ER-negative tumor subtype was predictive of this choice while timing of pregnancy was not.
Competing Interests: Declaration of interest No other authors have any disclosures.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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