The Effect of Effort During a Resistance Exercise Session on Glycemic Control in Individuals Living With Prediabetes or Type 2 Diabetes: Protocol for a Crossover Randomized Controlled Trial.

Autor:	Ramirez M; Department of Health, Exercise & Sports Sciences, College of Education and Human Sciences, University of New Mexico, Albuquerque, NM, United States., Gebauer M; Department of Health, Exercise & Sports Sciences, College of Education and Human Sciences, University of New Mexico, Albuquerque, NM, United States., Mermier C; Department of Health, Exercise & Sports Sciences, College of Education and Human Sciences, University of New Mexico, Albuquerque, NM, United States., Little JP; School of Health and Exercise Sciences, University of British Columbia - Okanagan Campus, Okanagan, BC, Canada., Lin L; Department of Individual, Family, and Community Education, College of Education and Human Sciences, University of New Mexico, Albuquerque, NM, United States., Palley G; Department of Family and Community Medicine, Health Science Center, University of New Mexico, Albuquerque, NM, United States., Hsiao YY; Department of Individual, Family, and Community Education, College of Education and Human Sciences, University of New Mexico, Albuquerque, NM, United States., Mota Alvidrez RI; Clinical and Translational Sciences Center, Pharmaceutical Sciences Department, University of New Mexico, Albuquerque, NM, United States., Mang ZA; Albuquerque Baseball Academy, Albuquerque, NM, United States., Amorim FT; Department of Health, Exercise & Sports Sciences, College of Education and Human Sciences, University of New Mexico, Albuquerque, NM, United States., Tricoli V; Department of Sport, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil., De Castro Magalhaes F; Department of Health, Exercise & Sports Sciences, College of Education and Human Sciences, University of New Mexico, Albuquerque, NM, United States.
Jazyk:	angličtina
Zdroj:	JMIR research protocols [JMIR Res Protoc] 2024 Nov 05; Vol. 13, pp. e63598. Date of Electronic Publication: 2024 Nov 05.
DOI:	10.2196/63598
Abstrakt:	Background: Type 2 diabetes (T2D) is preceded by prediabetes, and these conditions place a great burden on patients and society. These conditions are significantly associated with poor glycemic control, which is improved by resistance exercise. It has been suggested that resistance exercise should be performed with a high degree of effort to improve glucose metabolism, but this is associated with negative psychological responses that might lead to lower long-term adherence. Objective: This study aimed to investigate the effect of the degree of effort during a resistance exercise session on glycemic control and psychological responses in individuals living with prediabetes or T2D. Methods: This study will be a crossover, 3-arm, randomized controlled trial. A total of 15 participants living with prediabetes or T2D will be thoroughly familiarized with 7 resistance exercises; afterward, they will perform 3 randomized experimental sessions, each lasting approximately 48 hours each, separated by at least 4 washout days. In 2 of these sessions, supervised resistance exercise will be performed, but the sessions will differ in the degree of effort in each set (high vs low) and will be equalized in terms of total weight lifted and session duration. For this, proximity to failure will be manipulated by changing the number of sets per exercise, the number of repetitions per set, and the resting interval between sets and exercises. Participants will also complete a sedentary (control) session, where they will not perform any exercise. In response to each session, psychological responses will be assessed (exertion, affect, enjoyment, self-efficacy, and discomfort). Glycemic control will be assessed by a continuous glucose monitoring device every 5 minutes, throughout the approximately 48 hours of each experimental session. Food and drink will be individually prescribed by a registered dietitian nutritionist and provided to participants, in order to control for the confounding effect of energy intake and diet composition. Physical activity levels will be assessed by accelerometry. Randomization will be done using the opaque, sequentially numbered envelopes technique. Participants and researchers will be blinded for continuous glucose monitoring and accelerometry data, and data will be analyzed by a blinded statistician. Results: This study has been funded, and data collection is expected to take place between June 2024 and May 2025. Final manuscript submission should happen by August 2025. Conclusions: The results of this project might encourage individuals living with prediabetes and T2D to engage in resistance exercise while better informing exercise specialists on how to best incorporate resistance exercise in their client's or patient's routine. Trial Registration: ClinicalTrials.gov NCT06208189; https://clinicaltrials.gov/study/NCT06208189. International Registered Report Identifier (irrid): PRR1-10.2196/63598. (©Marissa Ramirez, Maja Gebauer, Christine Mermier, Jonathan Peter Little, Luotao Lin, Gabriel Palley, Yu Yu Hsiao, Roberto Ivan Mota Alvidrez, Zach A Mang, Fabiano Trigueiro Amorim, Valmor Tricoli, Flavio De Castro Magalhaes. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 05.11.2024.)
Databáze:	MEDLINE
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