Total testosterone, sex hormone-binding globulin, and free testosterone concentrations and risk of primary liver cancer: A prospective analysis of 200,000 men and 180,000 postmenopausal women.

Autor: Watling CZ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA., Kelly RK; The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.; School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia., Watts EL; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA., Graubard BI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA., Petrick JL; Slone Epidemiology Center, Boston University, Boston, Massachusetts, USA., Matthews CE; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA., McGlynn KA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Jazyk: angličtina
Zdroj: International journal of cancer [Int J Cancer] 2024 Nov 05. Date of Electronic Publication: 2024 Nov 05.
DOI: 10.1002/ijc.35244
Abstrakt: In most countries, males have ~2-3 times higher incidence of primary liver cancer than females. Sex hormones have been hypothesized to contribute to these differences, but the evidence remains unclear. Using data from the UK Biobank, which included ~200,000 males and ~180,000 postmenopausal females who provided blood samples at recruitment, we estimated hazard ratios (HR 2 ) and 95% confidence intervals (CI) for a doubling in hormone concentration from multivariable adjusted Cox regression for circulating total testosterone, sex-hormone binding globulin (SHBG), and free testosterone concentrations and risk of primary liver cancer. After a median of 11.8 years of follow-up, 531 cases of primary liver cancer were observed, of which 366 occurred in males and 165 occurred in females. Total testosterone and SHBG were shown to be positively associated with liver cancer risk in both males and females (Total testosterone HR 2 : 3.42, 95% CI:2.42-4.84 and 1.29, 0.97-1.72, respectively; SHBG HR 2 : 5.44, 4.42-6.68 and 1.52, 1.09-2.12, respectively). However, free testosterone was inversely associated with primary liver cancer in males (HR 2 : 0.42, 0.32-0.55) and no association was observed in females. When analyses compared two main liver cancer subtypes, hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), there was evidence of heterogeneity; associations for total testosterone and SHBG concentrations were only positively associated with HCC in both males (HR 2 : 3.56, 2.65-4.79 and 7.72, 6.12-9.73, respectively) and females (HR 2 : 1.65, 1.20-2.27 and 6.74, 3.93-11.5, respectively) but not with ICC. Further research understanding the mechanisms of how sex-steroids may influence liver cancer risk is needed.
(© 2024 The Author(s). International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.)
Databáze: MEDLINE
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