Impact of oral isotretinoin on the inflammatory markers: can lymphocyte/HDL-C and platelet/HDL-C ratios be new indicators of inflammation in acne vulgaris patients?
| Autor: | Zorlu Ö; Department of Dermatology and Venereology, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey., Albayrak H; Department of Dermatology and Venereology, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey., Aytekin S; Department of Dermatology and Venereology, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Cutaneous and ocular toxicology [Cutan Ocul Toxicol] 2024 Dec; Vol. 43 (4), pp. 383-389. Date of Electronic Publication: 2024 Nov 05. |
| DOI: | 10.1080/15569527.2024.2423257 |
| Abstrakt: | Introduction: The effect of isotretinoin on inflammatory markers has been reported with conflicting results. No studies have been reported on the relationship between isotretinoin and lymphocyte/high-density lipoprotein cholesterol [HDL-C] ratio (LHR), neutrophil/HDL-C ratio (NHR), or platelet/HDL-C ratio (PHR) in acne patients. Objectives: We aimed to investigate how isotretinoin affects the inflammatory markers, including LHR, NHR, and PHR, in acne vulgaris patients. Methods: A total of 361 patients with moderate-to-severe acne vulgaris who received systemic isotretinoin for at least six months were included. Complete blood count and biochemical analyses, including monocyte/HDL-C ratio (MHR), NHR, LHR, PHR, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), the aggregate index of systemic inflammation (AISI), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), obtained at the treatment onset and the end of the first, third, and sixth months of treatment were investigated. Results: There was no significant difference in MHR and NHR levels between repeated measures. A significant increasing trend was seen in LHR and PHR ( P = 0.001 and P = 0.011, respectively). HDL-C levels gradually and significantly declined during the six months ( P < 0.001). Serum NLR, derived NLR, SII, SIRI, MLR, and AISI showed a significant decrease in line with clinical improvement in acne during the six months of therapy ( P < 0.05). Conclusions: Declining levels of NLR, MLR, SII, SIRI, and AISI may indicate the anti-inflammatory effects of isotretinoin on the pilosebaceous unit, whereas increasing levels of LHR and PHR may show systemic inflammatory activity of isotretinoin. |
| Databáze: | MEDLINE |
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