FLIP: a novel method for patient-specific dose quantification in circulating blood in large vessels during proton or photon external beam radiotherapy treatments.
| Autor: | García-Cardosa M; Department of Physics and Applied Mathematics, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain., Meiriño R; Department of Radiation Oncology, Clínica Universidad de Navarra, Marquesado de Santa Marta 1, 28027 Madrid, Spain., Calvo FA; Department of Radiation Oncology, Clínica Universidad de Navarra, Marquesado de Santa Marta 1, 28027 Madrid, Spain., Antolín E; Service of Medical Physics and Radiation Protection, Clínica Universidad de Navarra, Marquesado de Santa Marta 1, 28027 Madrid, Spain., Aguilar B; Service of Medical Physics and Radiation Protection, Clínica Universidad de Navarra, Marquesado de Santa Marta 1, 28027 Madrid, Spain., Vidorreta M; Siemens Healthineers, 28043 Madrid, Spain., Cuevas R; Service of Medical Physics and Radiation Protection, Clínica Universidad de Navarra, Av. De Pío XII 36, 31008 Pamplona, Spain., Barbés B; Service of Medical Physics and Radiation Protection, Clínica Universidad de Navarra, Av. De Pío XII 36, 31008 Pamplona, Spain., Huesa-Berral C; Department of Physics and Applied Mathematics, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.; Department of Radiation Oncology, Physics Division, Massachusetts General Hospital, Boston, MA 02114, United States of America., Azcona JD; Service of Medical Physics and Radiation Protection, Clínica Universidad de Navarra, Marquesado de Santa Marta 1, 28027 Madrid, Spain., Burguete J; Department of Physics and Applied Mathematics, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, Irunlarrea 3, Pamplona 31008, Spain. |
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| Jazyk: | angličtina |
| Zdroj: | Physics in medicine and biology [Phys Med Biol] 2024 Nov 14; Vol. 69 (22). Date of Electronic Publication: 2024 Nov 14. |
| DOI: | 10.1088/1361-6560/ad8ea5 |
| Abstrakt: | Purpose. To provide a novel and personalized method ( FLIP, FLow and Irradiation Personalized) using patient-specific circulating blood flows and individualized time-dependent irradiation distributions, to quantify the dose delivered to blood in large vessels during proton or photon external beam radiotherapy. Methods. Patient-specific data were obtained from ten cancer patients undergoing radiotherapy, including the blood velocity field in large vessels and the temporal irradiation scheme using photons or protons. The large vessels and the corresponding blood flow velocities are obtained from phase-contrast MRI sequences. The blood dose is obtained discretizing the fluid into individual blood particles (BPs). A Lagrangian approach was applied to simulate the BPs trajectories along the vascular velocity field flowlines. Beam delivery dynamics was obtained from beam delivery machine measurements. The whole IS is split into a sequence of successive IEs, each one with its constant dose rate, as well as its corresponding initial and final time. Calculating the dose rate and knowing the spatiotemporal distribution of BPs, the dose is computed by accumulating the energy received by each BP as the time-dependent irradiation beams take place during the treatment. Results. Blood dose volume histograms from proton therapy and photon radiotherapy patients were assessed. The irradiation times distribution is obtained for BPs in both modalities. Two dosimetric parameters are presented: (i) D (© 2024 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.) |
| Databáze: | MEDLINE |
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