| Autor: |
Wang H; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Wei Y; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Lin G; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Boyer C; Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Jia KM; Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Hung CT; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Jiang X; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Li C; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Yam CHK; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Chow TY; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Wang Y; Division of Landscape Architecture, Department of Architecture, Faculty of Architecture, The University of Hong Kong, Hong Kong, China., Zhao S; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.; School of Public Health, Tianjin Medical University, Tianjin, People's Republic of China., Guo Z; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Li K; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Yang A; Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Mok CKP; Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China., Hui DSC; S.H. Ho Research Centre for Infectious Diseases, Chinese University of Hong Kong, Hong Kong, China., Chong KC; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Yeoh EK; School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China. |
| Abstrakt: |
While previous research examined coronavirus disease 2019 (COVID-19) antiviral-vaccine interactions through exploratory subgroup analysis, none specifically designed for examining this interaction or its impact on post-acute outcomes. This study examined the interaction between nirmatrelvir-ritonavir and complete COVID-19 vaccination on reducing the risk of post-acute outcomes among COVID-19 patients. We followed COVID-19 patients hospitalized between 11 March 2022 and 10 October 2023, until 31 October 2023 in Hong Kong. Exposure groups were based on nirmatrelvir-ritonavir usage and vaccination status (fully or not fully vaccinated). Post-acute death and all-cause rehospitalization were the study outcomes. Propensity score weighting was applied to balance covariates among exposure groups, including age, sex, Charlson Comorbidity Index, and concomitant treatments. Multiplicative and additive interactions between nirmatrelvir-ritonavir and vaccination status were assessed. A total of 50,438 COVID-19 patients were included in this study and arranged into four exposure groups. Significant additive interaction on post-acute rehospitalization was observed (relative excess risk, 0.10; 95% CI, 0.02-0.19; p -value, 0.018; attributable proportion, 0.07; 95% CI, 0.01-0.12; p -value, 0.017; synergy index, 1.26; 95% CI, 1.02-1.55; p -value, 0.032). The interaction on post-acute mortality was marginally significant. In the subgroup analysis, the interaction effect is more pronounced in older adults, female, and CoronaVac recipients. In conclusion, our study demonstrated an additive interaction between nirmatrelvir-ritonavir and complete vaccination on post-acute outcomes, suggesting greater long-term benefits of the antiviral for fully vaccinated individuals compared to not fully vaccinated patients. |
