The funnel effect of reserves prompted by leisure activities across the Alzheimer's disease continuum.

Autor:	Serra L; Neuroimaging Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy., Bonarota S; Neuroimaging Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy., Di Domenico C; Neuroimaging Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy.; Department of Psychology, Sapienza University of Rome, Rome, Italy., Caruso G; SC Neurologia Ospedaliera, Policlinico Riuniti di Foggia, Foggia, Italy., Giulietti G; Neuroimaging Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy.; SAIMLAL Department, Sapienza University, Rome, Italy., Rizzuti M; Department of Human Sciences, Guglielmo Marconi University, Rome, Italy., Assogna M; Experimental Neuropsychophysiology Laboratory, Fondazione Santa Lucia IRCCS, Roma, Italy., Rodini M; Experimental Neuropsychophysiology Laboratory, Fondazione Santa Lucia IRCCS, Roma, Italy., Mencarelli L; Experimental Neuropsychophysiology Laboratory, Fondazione Santa Lucia IRCCS, Roma, Italy., Di Lorenzo F; Experimental Neuropsychophysiology Laboratory, Fondazione Santa Lucia IRCCS, Roma, Italy., Koch G; Experimental Neuropsychophysiology Laboratory, Fondazione Santa Lucia IRCCS, Roma, Italy.; Department of Neuroscience and Rehabilitation University of Ferrara, Ferrara, Italy., Fadda L; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.; Clinical and Behavioral Neurology Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy., Caltagirone C; Scientific Direction, Fondazione Santa Lucia IRCCS, Rome, Italy., Bozzali M; Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy.
Jazyk:	angličtina
Zdroj:	Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024 Nov; Vol. 102 (1), pp. 181-194. Date of Electronic Publication: 2024 Oct 17.
DOI:	10.1177/13872877241284211
Abstrakt:	Background: Reserves' mechanisms explain inconsistencies between accumulation of neuropathological damage and clinical manifestations. Leisure activities are believed to promote reserves. Objective: This study evaluates whether cognitive, social, and physical leisure activities performed over life-span predict current cognitive functioning in normal aging and Alzheimer's disease (AD) continuum. Methods: 35 AD, 24 amnestic-Mild Cognitive Impairment (a-MCI) patients, 21 individuals with subjective cognitive complaint (SCD), and 25 controls underwent a questionnaire developed to quantify leisure activities in different life periods, the Addenbrooke's Cognitive Examination-Revised (ACE-R), and T1-weighted 3T-MRI scans for brain volumetrics and cortical thickness quantification. Partial/total leisure activities' scores and demographic and brain variables were entered as predictors, while ACE-R scores as dependent variables in linear regression analyses. Results: Current level of cognition was predicted by (i) social and physical activities performed in middle age and current cognitive activity in AD; (ii) cognitive and social activities performed in middle age, current age and cortical thickness in a-MCI; (iii) recreational activities the set of lifetime, current age, and brain features in SCD; (iv) education and the set of lifetime leisure activities over lifespan in controls. Conclusions: This study shows a funnel effect due to gradual reduction of stimulatory activities in the transition from healthy aging to AD. Reserve indices taking into account different types of stimulatory activities allow to capture even smallest residual effects of reserves accumulated over lifespan, until their complete depletion at advanced AD stages. These results may help target tailored interventions during normal and pathological aging. Competing Interests: Declaration of conflicting interestsL.S. and M.B. are Editorial Board Members of this journal but were not involved in the peer-review process of this article nor had access to any information regarding its peer-review. The remaining authors have no conflict of interest to report.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu