Long COVID and recovery from Long COVID: quality of life impairments and subjective cognitive decline at a median of 2 years after initial infection.

Autor: Szewczyk W; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA. warrenjs@uw.edu., Fitzpatrick AL; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Fossou H; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Gentile NL; Department of Family Medicine, School of Medicine, University of Washington, Seattle, WA, USA., Sotoodehnia N; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Vora SB; Division of Infectious Diseases, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA, USA., West TE; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA., Bertolli J; Centers for Disease Control and Prevention, Atlanta, GA, USA., Cope JR; Centers for Disease Control and Prevention, Atlanta, GA, USA., Lin JS; Centers for Disease Control and Prevention, Atlanta, GA, USA., Unger ER; Centers for Disease Control and Prevention, Atlanta, GA, USA., Vu QM; Centers for Disease Control and Prevention, Atlanta, GA, USA.
Jazyk: angličtina
Zdroj: BMC infectious diseases [BMC Infect Dis] 2024 Nov 05; Vol. 24 (1), pp. 1241. Date of Electronic Publication: 2024 Nov 05.
DOI: 10.1186/s12879-024-10158-w
Abstrakt: Background: Recovery from SARS CoV-2 infection is expected within 3 months. Long COVID occurs after SARS-CoV-2 when symptoms are present for more than 3 months that are continuous, relapsing and remitting, or progressive. Better understanding of Long COVID illness trajectories could strengthen patient care and support.
Methods: We characterized functional impairments, quality of life (QoL), and cognition among patients who recovered from SARS-CoV-2 infection within 3 months (without Long COVID), after 3 months (Recovered Long COVID), or remained symptomatic (Long COVID). Among 7305 patients identified with previous SARS-CoV-2 infection between March 2020 and December 2021, confirmed in the medical record with laboratory test or physician diagnosis, 435 (6%) completed a single self-administered survey between March 2022 and September 2022. Multi-domain QoL and cognitive concerns were evaluated using PROMIS-29 and the Cognitive Change Index-12.
Results: Nearly half the participants (47.7%) were surveyed more than 2 years from initial infection (median = 23.3 months; IQR = 18.6, 26.7) and 86.7% were surveyed more than 1 year from infection. A significantly greater proportion of the Long COVID (n = 215) group, (Current and Recovered combined), had moderate-to-severe impairment in all health domains assessed compared to those Without Long COVID (n = 220; all p < 0.05). The Recovered Long COVID group (n = 34) had significantly lower prevalence of fatigue, pain, depression, and physical and social function impairment compared to those with Current Long COVID (n = 181; all p < 0.05). However, compared to patients Without Long COVID, the Recovered Long COVID group had greater prevalences of fatigue, pain (p ≤ 0.06) and subjective cognitive decline (61.8% vs 29.1%; p < 0.01). Multivariate relative risk (RR) regression indicated Long COVID risk was greater for older age groups (RR range 1.46-1.52; all p ≤ 0.05), those without a bachelor's degree (RR = 1.33; 95% CI = 1.03-1.71; p = 0.03), and those with 3 or more comorbidities prior to SARS-CoV-2 infection (RR = 1.45; 95% CI = 1.11-1.90; p < 0.01).
Conclusions: Long COVID is associated with long-term subjective cognitive decline and diminished quality of life. Clinically significant cognitive complaints, fatigue, and pain were present even in those who reported they had recovered from Long COVID. These findings have implications for the sustainability of participation in work, education, and social activities.
(© 2024. The Author(s).)
Databáze: MEDLINE
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