Tracking of Vascular Measures From Infancy to Early Childhood: A Cohort Study.

Autor: Mansell T; Murdoch Children's Research Institute, Royal Children's Hospital Parkville Melbourne Australia.; Department of Paediatrics University of Melbourne Parkville Melbourne Australia., Nuotio J; Murdoch Children's Research Institute, Royal Children's Hospital Parkville Melbourne Australia.; Research Centre of Applied and Preventive Cardiovascular Medicine University of Turku Finland.; Centre for Population Health Research University of Turku and Turku University Hospital Turku Finland.; Heart Centre Turku University Hospital and University of Turku Finland., Vuillermin P; School of Medicine Deakin University Geelong Australia.; Barwon Health Geelong Australia., Ponsonby AL; Murdoch Children's Research Institute, Royal Children's Hospital Parkville Melbourne Australia.; Department of Paediatrics University of Melbourne Parkville Melbourne Australia.; Florey Institute of Neuroscience and Mental Health University of Melbourne Melbourne Australia., Lawlor DA; Integrative Epidemiology Unit, University of Bristol UK.; Population Health Sciences, Bristol Medical School University of Bristol UK., McCloskey K; School of Medicine Deakin University Geelong Australia.; Barwon Health Geelong Australia., Juonala M; Murdoch Children's Research Institute, Royal Children's Hospital Parkville Melbourne Australia.; Department of Medicine, University of Turku and Division of Medicine Turku University Hospital Turku Finland., Burgner DP; Murdoch Children's Research Institute, Royal Children's Hospital Parkville Melbourne Australia.; Department of Paediatrics University of Melbourne Parkville Melbourne Australia.; Department of Paediatrics Monash University Melbourne Australia.
Jazyk: angličtina
Zdroj: Journal of the American Heart Association [J Am Heart Assoc] 2024 Nov 05; Vol. 13 (21), pp. e036611. Date of Electronic Publication: 2024 Nov 04.
DOI: 10.1161/JAHA.124.036611
Abstrakt: Background: Atherosclerosis develops across the life course, and variation in aortic intima-media thickness (IMT) is evident from infancy onward, although most early-life data are cross-sectional. We investigated whether abdominal aortic IMT at age 6 weeks is associated with vascular measures at 4 years and the relationship of prenatal and perinatal exposures with these measures in early childhood.
Methods and Results: We analyzed data from 518 participants with 6-week and 4-year vascular measures from the Barwon Infant Study. Aortic IMT was measured at 6 weeks (mean, 6.1±SD 1.5 weeks) and aortic and carotid IMT, carotid-femoral pulse wave velocity, and blood pressure at 4 years of age (4.3±0.3 years). Associations of early-life exposures-maternal enteric microbiome, smoking and low-density lipoprotein cholesterol during pregnancy, birth weight, and gestational age-were also investigated. In the primary model, 6-week aortic IMT (649±66 μm) was associated with small differences in 4-year carotid IMT (453±45 μm) (mean difference in carotid IMT per 100 μm higher 6-week aortic IMT=7.0 μm [95% CI, 0.7-13.3]; P =0.03), with no evidence for associations with 4-year aortic IMT, pulse wave velocity, or blood pressure. Higher birth weight was associated with greater 4-year aortic IMT, and maternal smoking with higher systolic blood pressure.
Conclusions: Vascular measures do not show strong evidence of tracking between infancy and early childhood. Longitudinal studies with repeated assessment beyond age 4 years would inform optimal timing of early prevention and targets for primordial prevention.
Databáze: MEDLINE
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